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    1. Developmental Biology

    The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra)–phosphoinositide 3-kinase (PI3K) signaling cascade to steer toward the midline during zebrafish heart tube formation

    Rabina Shrestha, Tess McCann ... Joshua Bloomekatz
    Research on heart tube assembly using zebrafish reveals a pivotal role for intrinsic Pdgfra–PI3K signaling in steering the movement of the myocardium and polarizing myocardial cell protrusions.
    1. Developmental Biology

    The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis

    Christian SM Helker, Annika Schuermann ... Wiebke Herzog
    Elabela-Apelin receptor signaling is a novel pathway that regulates angioblast migration, instead of the proposed migration regulation through Vascular endothelial growth factor.
    1. Cell Biology
    2. Developmental Biology

    Ciliary Hedgehog signaling regulates cell survival to build the facial midline

    Shaun R Abrams, Jeremy F Reiter
    Genetic analysis identifies the origins of midface defects in mouse models of ciliopathies, revealing a role for ciliary Hedgehog signaling in cell survival.
    1. Cancer Biology

    BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas

    Paul Huchede, Swann Meyer ... Marie Castets
    BMP2 and 7 synergize with H3.3K27M epigenetic context to establish a quiescent but invasive state in pediatric diffuse midline gliomas.
    1. Genetics and Genomics
    2. Structural Biology and Molecular Biophysics

    Structure-guided isoform identification for the human transcriptome

    Markus J Sommer, Sooyoung Cha ... Steven L Salzberg
    The ability to accurately predict a protein's structure gives us an entirely new way to annotate the human genome.
    1. Developmental Biology
    2. Neuroscience

    DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation

    Laura Morcom, Ilan Gobius ... Linda J Richards
    Axon guidance molecules DCC and NTN1 regulate astroglial-mediated interhemispheric remodelling required for corpus callosum formation in humans and mice.
    1. Neuroscience

    Population rate-coding predicts correctly that human sound localization depends on sound intensity

    Antje Ihlefeld, Nima Alamatsaz, Robert M Shapley
    Softer sound appears closer to midline than louder sound, conflicting with a labelled-line representation of auditory space and supporting the idea that humans use rate coding when calculating sound directionality.
    1. Cell Biology
    2. Developmental Biology

    Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis

    Eric Paulissen, Nicholas J Palmisano ... Benjamin L Martin
    Retinoic acid-dependent somite morphogenesis induces notochord-endoderm separation required for midline angioblast migration and axial blood vessel development.
    1. Neuroscience

    Sonic Hedgehog switches on Wnt/planar cell polarity signaling in commissural axon growth cones by reducing levels of Shisa2

    Keisuke Onishi, Yimin Zou
    Sonic Hedgehog signaling may temporally and spatially activate planar cell polarity signaling for cellular and tissue morphogenesis.
    1. Cell Biology

    Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel

    Tengteng Huang, Xiaoling Chen ... Zhiqing Huang
    Eugenol has the potential as a novel exercise mimetic, and TRPV1 may represent a promising target for the development of exercise mimetics.