Axon guidance molecules DCC and NTN1 regulate astroglial-mediated interhemispheric remodelling required for corpus callosum formation in humans and mice.

Incomplete interhemispheric fissure remodelling determines corpus callosum size in humans and BTBR N2 mice that carry a deletion in Draxin.

Loss of function of the selective autophagy adaptor protein Alfy/Wdfy3 leads to profound wiring defects from the forebrain through to the spinal cord, highlighting the growing importance for macroautophagy in the developing brain.

An ancestral apical brain center contributed to the evolution of the insect central complex requiring foxQ2, which is essential for the development of midline structures of the insect brain.

TIR-1 regulates both repair and destruction on either side of an injury axon.

Hif/Hif-3α has two distinct roles in cells: activating HRE-dependent gene expression and binding to β-catenin to destabilize the nuclear β-catenin complex.