3,260 results found
    1. Developmental Biology
    2. Medicine

    CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

    Hironobu Okuno et al.
    Neural crest cells differentiated from patient-derived cells with mutations in the chromatin remodeler CHD7 show defective delamination, migration and motility in vitro, and defective migration in chick embryos.
    1. Developmental Biology

    Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo

    Bechara Saykali et al.
    At gastrulation, mesoderm arises as a migratory germ layer that will participate to both foetal and placental development through region-dependant adaptation of cytoskeleton composition, cell shape and migration mode.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Nephron progenitor commitment is a stochastic process influenced by cell migration

    Kynan T Lawlor et al.
    Stochastic cell migration modulates exposure to signals that regulate commitment in the nephron progenitor niche.
    1. Biochemistry and Chemical Biology

    Random-sequence genetic oligomer pools display an innate potential for ligation and recombination

    Hannes Mutschler et al.
    Random sequence RNA pools display an innate capacity for ligation and recombination, enabling them to “bootstrap” themselves towards higher compositional, informational and structural complexity.
    1. Chromosomes and Gene Expression

    Assessing long-distance RNA sequence connectivity via RNA-templated DNA–DNA ligation

    Christian K Roy et al.
    SeqZip is a new DNA ligation-based method to condense and maintain exon connectivity information within individual RNA molecules, which can provide new insights into alternative splicing.
    1. Ecology

    5α-cyprinol sulfate, a bile salt from fish, induces diel vertical migration in Daphnia

    Meike Anika Hahn et al.
    A fish-derived bile salt was shown to act as interspecific infochemical, inducing the widespread predator avoidance behavior diel vertical migration at picomolar concentrations in freshwater zooplankton of the genus Daphnia.
    1. Cell Biology
    2. Computational and Systems Biology

    An analysis toolbox to explore mesenchymal migration heterogeneity reveals adaptive switching between distinct modes

    Hamdah Shafqat-Abbasi et al.
    “Discontinuous” and “Continuous” migration modes are divergent mesenchymal migration strategies that arise spontaneously in parallel in an equilibrium modulated by cell-matrix attachment and actomyosin contractility.
    1. Structural Biology and Molecular Biophysics

    Measuring the sequence-affinity landscape of antibodies with massively parallel titration curves

    Rhys M Adams et al.
    The absolute affinities of thousands of variant antibodies are measured in parallel using a combination of cell sorting and high-throughput DNA sequencing.
    1. Cell Biology
    2. Developmental Biology

    Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

    Lu Wei et al.
    Notch signaling controls the collective migration of parapineal cells through its capacity to restrict FGF pathway activation to a few leading cells.
    1. Developmental Biology
    2. Neuroscience

    GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation

    Meghan Morgan-Smith et al.
    The kinase GSK-3 regulates cortical neuronal migration and dendritic orientation by phosphorylating key cytoskeletal proteins.

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