8,082 results found
    1. Neuroscience

    Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis

    Mahdokht Kohansal-Nodehi et al.
    Global phosphoproteomic analysis in nerve terminal during exocytosis reveals 252 uniquely regulated phosphosites, highlighting complex regulation of active zone proteins at multiple sites and the role of specific kinases/phosphatases.
    1. Microbiology and Infectious Disease

    Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration

    Malgorzata Broncel et al.
    Myristoylation of a secreted protein, identified in a global myristoylation analysis of the eukaryotic parasite Toxoplasma gondii, is important for host cell invasion.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter

    Aaron T Bozzi et al.
    Nramp-family transporters adapt a common fold to a novel mechanism in which the spatial and temporal separation of like-charge transition metal and proton co-substrates circumvents the expected electrostatic repulsion.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Protein sequences bound to mineral surfaces persist into deep time

    Beatrice Demarchi et al.
    A chemically unstable ostrich eggshell peptide survives for at least 3.8 million years at the equator, stabilized by strong mineral interactions.
    1. Evolutionary Biology

    Adaptation in protein fitness landscapes is facilitated by indirect paths

    Nicholas C Wu et al.
    The extra dimensions in protein sequence space open up indirect paths of adaptation and alleviate the constraint on the selective accessibility to high fitness genotypes.
    1. Physics of Living Systems

    Cell-sized confinement controls generation and stability of a protein wave for spatiotemporal regulation in cells

    Shunshi Kohyama et al.
    A cell-sized fully confined space significantly controls the emergence and stability of a protein wave, resulting in intracellular spatiotemporal regulation driven by a reaction-diffusion mechanism.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

    George Ueda et al.
    De novo protein nanoparticles were designed from scratch to present viral glycoprotein antigens, providing a systematic way to study the influence of antigen presentation geometry on immune response.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Viruses are a dominant driver of protein adaptation in mammals

    David Enard et al.
    Viruses drive adaptation at the scale of the whole proteome and not only in antiviral proteins in mammalian hosts.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Engineering a conserved RNA regulatory protein repurposes its biological function in vivo

    Vandita D Bhat et al.
    Motif length plays a critical role in the specification of biological function within a conserved family of RNA-binding proteins.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

    Shuping Zhang et al.
    The heme and HRI-mediated eIF2aP–ATF4 integrated stress response in erythropoiesis has a major global impact, especially under the stress condition of iron deficiency.

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