A physiological mathematical model of chronic myeloid leukemia, validated by experiments in transgenic mice and clinical data, identifies mechanisms underlying the response to tyrosine kinase inhibitor therapy, predicts biomarkers of primary resistance, and suggests new strategies to improve treatment outcomes.

The effective higher-order binding cooperativities arising from an ensemble of dynamically interchanging conformations are identified and shown to fully describe integration of binding information at thermodynamic equilibrium.

Real-time imaging of neural activity in behaving mice reveals that the two canonical types of neurons in the olfactory tubercle carry distinct information about learned odor cues, with D1 neurons representing stimulus valence and D2 neurons mainly representing stimulus identity.

Postmated increases in sucrose consumption in Drosophila melanogaster females is executed by a female specific circuit that alters neuroendocrine centers to promote hunger.

Drosophila enteroblasts form septate junctions, an apical domain and an internal lumen inside the midgut epithelium before they reach the gut surface, thereby maintaining the intestinal barrier as they integrate.

Absolute quantification of CTCF and cohesin reveals quantitative constraints on 3D genome organization and illuminates the molecular architecture of the cohesin complex.

Notch signaling regulates the neuroblast intrinsic temporal program to determine when neuroblasts terminate their cell divisions during development.

Tracking proteins in live cells is challenging due to technical limitations and biological complexity, but approaches based in Bayesian nonparametrics stand a decent chance at recovering a target protein's dynamic profile from noisy data.

Lactate in pancreatic cancer micro-environment can lead to TET enzyme activation and loss of DNA methylation seen in cancer associated fibroblasts.