51 results found
    1. Cell Biology

    circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis

    Minmin Song et al.
    Upregulation of circPTPN12 in endometrial epithelial cells (EECs) of fibrotic endometrium sponged miR-21–5 p and resulted in upregulation of its target gene, ΔNp63α, which induced transition of EECs to mesenchymal cells.
    1. Computational and Systems Biology
    2. Medicine

    Identification of human glucocorticoid response markers using integrated multi-omic analysis from a randomized crossover trial

    Dimitrios Chantzichristos et al.
    A human experimental model for physiological glucocorticoid exposure and glucocorticoid withdrawal identifies a multi-omic cluster, including microRNA miR-122-5p and metabolites, associated with glucocorticoid-responsive genes.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    MicroRNA-deficient mouse embryonic stem cells acquire a functional interferon response

    Jeroen Witteveldt et al.
    MiRNA-mediated suppression of MAVS expression in embryonic stem cells is necessary to inactivate the type I interferon response.
    1. Neuroscience

    The actin-modulating protein synaptopodin mediates long-term survival of dendritic spines

    Kenrick Yap et al.
    Long-term imaging of dentate granule cells reveals that the presence of synaptopodin within large spines, rather than their size, conveys long-term stability to large spines.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche

    Kacy L Gordon et al.
    A previously undetected dynamic cell structure orients the mitotic spindle of germ stem cells and grows over one daughter cell, thus helping to balance niche retention with niche exit.
    1. Neuroscience

    Pretectal neurons control hunting behaviour

    Paride Antinucci et al.
    A discrete population of genetically accessible pretectal neurons controls visually guided hunting behaviour in larval zebrafish.
    1. Cell Biology
    2. Computational and Systems Biology

    A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis

    Stefania Rosano et al.
    Coordinated microRNAs activity induced by VEGF represses cell proliferation and favors cell migration at the onset of sprouting angiogenesis in endothelial cells.
    1. Chromosomes and Gene Expression

    Importance of miRNA stability and alternative primary miRNA isoforms in gene regulation during Drosophila development

    Li Zhou et al.
    Selective degradation of mature miRNAs shapes temporal miRNA expression patterns and is important for proper regulation of target genes to support normal development of Drosophila embryos.
    1. Developmental Biology
    2. Neuroscience

    Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

    Christine J Huh et al.
    MicroRNA-based direct conversion of human fibroblasts to neurons is applicable to fibroblasts from donors ranging in age from neonatal to centenarian, allowing the generation of neurons that maintain the age-associated signatures of the starting fibroblasts.
    1. Computational and Systems Biology
    2. Developmental Biology

    Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

    Nick E Phillips et al.
    Stochasticity introduced computationally into a gene expression oscillator creates heterogeneity in the time of differentiation of identical cells and offers robustness to the progenitor state and the outcome of cell division.

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