Maternal spindle transfer is a feasible approach to enhance embryonic developmental of compromised oocytes, which can represent a new strategy for patients with forms of infertility refractory to current treatments.

A new high-throughput method for single-cell RNA-seq in yeast cells shows how stochastic expression of glucose-repressed genes contributes to cell-to-cell differences during adaptation to an environmental change.

Fluorescent glutamate indicators distort the time course of neurotransmitter diffusion and uptake by competing with transporters, an important caveat to consider when using iGluSnFR and its analogs.

Crystallography together with electron-resonance spectroscopy, molecular-dynamics simulations, and transport measurements reveal the molecular details of protein conformational change, and how this change contributes to function in a CLC-type chloride/proton exchanger.

The interaction between activated αIIbβ3 on platelets and SLC44A2 on circulating neutrophils facilitates neutrophil capture and drives flow-dependent NETosis.

Newly formed tetraploid cells rapidly lose extra centrosomes acquired upon tetraploidization via asymmetric centrosome clustering during cell division and selective advantage of tetraploid daughter cells that inherit a single centrosome.

Evidence suggests that the oskar gene, a critical germ line determinant in insects, was formed by fusion of bacterial and eukaryotic sequences at least 450 million years ago.

GABAergic postsynaptic responses mediated by spontaneous and evoked neurotransmitter release are partially segregated, suggesting they may serve distinct roles in neuronal signaling.

The meiotic recombination landscape in vertebrates was re-engineered via the co-evolution of a dual histone H3K4/H3K36 methylation 'writer' PRDM9 and its 'reader' ZCWPW1 that facilitates efficient double strand break repair.

LKB1 instructs the timing and location of synapse layer emergence in the outer retina by coordinating the regulation of pre- and postsynaptic neuron maturation and transport of synapse-associated proteins.