ATG9-dependent autophagy is an essential pathway for long-term survival within the cyst in the parasite Toxoplasma gondii and could be exploited in future studies seeking interventions against persistent Toxoplasma infection.
This review considers the evolutionary processes and physiological mechanisms that maintain or end pregnancy in mammals to formulate general, testable theoretical models that provide insights into the biology of parturition.
Hypoplastic left heart syndrome is reflected by reduced proliferative capacity of patient iPSC-derived cardiomyocytes and requires the activity of LRP2/APOB proteins, likely in conjunction with SHH and WNT signaling pathways.
TcMAC21 is an appropriate “next gen” mouse model for DS research, and provides a proof of concept of using artificial chromosomes to generate non-mosaic humanized animal models of chromosome disorders.
Naive hPSCs can readily give rise to human trophoblast stem cells, thus demonstrating their extraembryonic lineage potential and providing a new model system to study human trophectoderm specification.