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    1. Immunology and Inflammation

    The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice

    Alexandra a Aybar-Torres, Lennon A Saldarriaga ... Lei Jin
    The common human HAQ,AQ alleles suppress STING1 gain-of-function mutation-induced chronic STING1 inflammation in mice.
    1. Physics of Living Systems

    Intracellular mechanical fingerprint reveals cell type specific mechanical tuning

    Till M. Muenker, Bart E. Vos, Timo Betz
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans

    Yanan Sun, Meijiao Li ... Xiaochen Wang
    Cell biological and genetic studies reveal age-associated alterations of lysosomes and modulation of lysosomal activity by longevity pathways.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Overflow metabolism originates from growth optimization and cellheterogeneity

    Xin Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cell Biology

    Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

    Laura Childers, Jieun Park ... Michel Bagnat
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Dissociation of the nuclear basket triggers chromosome loss in aging yeast

    Mihailo Mirkovic, Jordan McCarthy ... Yves Barral
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Cell Biology
    2. Computational and Systems Biology

    The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies

    Jennifer EL Diaz, Mehmet Eren Ahsen ... Gustavo Stolovitzky
    The transcriptomic profiles of the constituent monotherapies of synergistic drug pairs tend to be correlated and result in novel gene expression in the combinations.
    1. Developmental Biology

    Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing

    Madeline M Keenen, Liheng Yang ... Carolyn B Coyne
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Cell Biology

    PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity

    Insook Jang, Anita Pottekat ... Randal J Kaufman
    The major protein disulfide isomerase family member, PDIA1, is essential in beta cells of mice fed a high-fat diet to maintain glucose homeostasis, proinsulin maturation and organelle integrity.
    1. Neuroscience

    Morphology and ultrastructure of external sense organs of Drosophila larvae

    Vincent Richter, Anna Rist ... Andreas S. Thum
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
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