Extensive mass spectrometry-based profiling of polar metabolites within synaptic vesicles that are rapidly isolated either from cultured mouse neurons or directly from mouse brains reveals their neurotransmitter composition.
A large interneuron in the Drosophila mushroom body has compartmentalized activity, which causes localized inhibition and predicts that Kenyon cells inhibit themselves more than they inhibit other individual Kenyon cells.
Colorectal tumors down-regulate the mitochondrial Na+/Ca2+/Li+ exchanger (NCLX) to alter mitochondrial Ca2+ signaling and initiate transcriptional and metabolic reprogramming that drives tumor chemo-resistance and metastasis.
Human plasma contains protein-protected mRNA fragments, myriad repeat RNAs, and novel intron RNAs, including a family of structured full-length excised introns, some corresponding to mirtron pre-miRNAs and agotrons.
H2O2-induced phosphorylation at Ser232 of Pex14 spatiotemporally regulates peroxisomal import of catalase, functioning in counteracting action against oxidative stress by the increase of cytosolic catalase.
RORβ is a key layer 4 transcription factor orchestrating a critical juncture in barrel development where terminal differentiation and activity inputs are integrated to drive cellular organization in the cortex.
The transcription factor, MEF2C, mediates a change in approximately one half of the expressed frontal cortical transcriptome controlling cellular metabolism and synaptic strength in response to acute loss of sleep.