207 results found
    1. Biochemistry and Chemical Biology

    Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria

    Sara M Nowinski et al.
    Mitochondrial fatty acid synthesis is best known for producing lipoic acid, however, longer acyl chain products regulate mitochondrial electron transport chain assembly, oxidative TCA cycle metabolism, and skeletal myoblast differentiation.
    1. Biochemistry and Chemical Biology

    The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis

    Jonathan G Van Vranken et al.
    The essential function of ACP is not related to mitochondrial fatty acid and lipoic acid synthesis, but rather an evolutionarily-conserved role in iron sulfur cluster biogenesis.
    1. Immunology and Inflammation

    Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function

    Marie Bettonville et al.
    Long-term exposure to recipient's alloantigens promotes major metabolic defects in T cells that are independent of PD-1-mediated regulation.
    1. Cell Biology

    AMPK and vacuole-associated Atg14p orchestrate μ-lipophagy for energy production and long-term survival under glucose starvation

    Arnold Y Seo et al.
    Upon AMPK activation by acute glucose restriction, Atg14p shifts its distribution from ER exit sites to liquid-ordered membrane domains on the vacuolar surface where, together with Atg6p, it facilitates LD-specific autophagy (i.e., microautophagy of lipid droplets) for energy production and long-term survival of starved cells.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides

    Samuel T Coradetti et al.
    Using barcoded mutagenesis and a high-throughput genetic screen results in the identification of 150 genes that affect lipid accumulation in a non-model yeast system.
    1. Developmental Biology

    Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

    Gianpaolo Rando et al.
    Glucocorticoid receptor directly regulates the transcriptional activity of peroxisome proliferator-activated alpha (PPARα) before birth in anticipation of the sudden shifts in the postnatal nutrient source and metabolic demands.
    1. Cell Biology

    Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance

    Shankar Mukherji, Erin K O'Shea
    A systematic comparison of experimentally measured and theoretically predicted magnitudes of organelle abundance fluctuations suggests that budding yeast produces the maximum level of variability in organelle abundance that can be generated by organelle biogenesis pathways.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Massive endocytosis triggered by surface membrane palmitoylation under mitochondrial control in BHK fibroblasts

    Donald W Hilgemann et al.
    Mitochondria can trigger massive endocytosis by releasing coenzyme A into the cytoplasm and thereby promoting the addition of fatty acids to surface membrane proteins.
    1. Evolutionary Biology

    Membranes, energetics, and evolution across the prokaryote-eukaryote divide

    Michael Lynch, Georgi K Marinov
    The common view that the mitochondrion endowed eukaryotes with a boost in bioenergetic capacity above that in prokaryotes is inconsistent with a diversity of cellular features.
    1. Cell Biology

    Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

    Nuno Rocha et al.
    Specific human mitofusin 2 mutations induce selective upper body obesity with suppressed leptin expression and severe adipose mitochondrial dysfunction.

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