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Genetic screens and functional assays utilizing reporter mRNAs triggering NGD or COMD provide a basis for understanding the unique contributions of each pathway to translation-coupled mRNA decay and contextualizes their effects in the larger cellular process of translation surveillance.

Adult cochlear supporting cells (SCs) are plastic and respond to ectopic Ikzf2 and Atoh1, and hair cell damage by up-regulating HC and down-regulating their endogenous SC genes.

Structural neuroimaging of 40,087 individuals identifies a distinct brain morphological profile associated with metabolic syndrome, linking cardiometabolic risk to cognitive performance, microscale tissue composition, and macroscale brain network architecture.

Eukaryotic translation elongation factor 1A1 controls the process of heat shock response, from transcriptional activation of the HSP70 gene, to HSP70 mRNA stabilization, nuclear export, and translation.

Mid-gestational exposure to maternal immune activation drives a sequence of transcriptional signatures and developmental pathology in embryonic mouse cortex, culminating in altered lamination and cellular lineage specification.

Protein changes in cerebral cortex following a mild traumatic brain injury (mTBI) identified herein will help in the development of monitoring and response biomarkers that may translate to clinical mTBI.

In vivo modulation of the prostaglandin, interferon, or granulocyte colony-stimulating factor pathway induces rapid and specific transcriptional changes in hematopoietic stem cells with significant heterogeneity in the cellular response.

Analysis of mouse zygotic genome activation (ZGA) reveals that a mis-annotated multicopy homeobox gene Obox4 functions redundantly with Dux to promote ZGA.

Homology information implicit in regions of conserved synteny allows quantification of gene origination by complete sequence divergence, revealing a larger-than-expected role for other mechanisms of origin, including de novo origination.

Single-cell multiomics reveals the gene regulatory networks and enhancer logic underlying two distinct wound response cell states in the Drosophila wing imaginal disc and finds similarities with cell states observed in the Ras-scrib tumor model.