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    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3

    Francesco Beghini, Lauren J McIver ... Nicola Segata
    The bioBakery 3 platform enables improved, integrated, and strain-level analysis of microbial communities from large-scale meta-omic data.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity

    Xue-Song Zhang, Jackie Li ... Martin J Blaser
    Alteration of host gut microbiota by antibiotic exposure in early life remodeled host intestinal immune development and metabolism and enhanced the induction of type 1 diabetes in genetically predisposed animals.
    1. Evolutionary Biology

    A dual endosymbiosis supports nutritional adaptation to hematophagy in the invasive tick Hyalomma marginatum

    Marie Buysse, Anna Maria Floriano ... Olivier Duron
    The invasive tick Hyalomma marginatum relies on a dual partner nutritional system to provide B vitamins and avoid nutritional deficiencies due to its exclusive blood diet.
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe

    Marisa A Yonemitsu, Rachael M Giersch ... Michael J Metzger
    A transmissible cancer that arose in a marine mussel spread from a single animal to become a global pathogen affecting two other mussel species in both Europe and South America.
    1. Microbiology and Infectious Disease

    Small RNAs from mitochondrial genome recombination sites are incorporated into T. gondii mitoribosomes

    Sabrina Tetzlaff, Arne Hillebrand ... Christian Schmitz-Linneweber
    Sequences at mitochondrial genome recombination sites are dually used as mRNAs and as rRNAs in actively translating mitoribosomes of T. gondii.
    1. Genetics and Genomics

    Science Forum: The critical importance of vouchers in genomics

    Janet C Buckner, Robert C Sanders ... Prosanta Chakrabarty
    Geneticists should include links to and information about permanently preserved voucher specimens on genome databases and publications.
    1. Microbiology and Infectious Disease

    MetaHiC phage-bacteria infection network reveals active cycling phages of the healthy human gut

    Martial Marbouty, Agnès Thierry ... Romain Koszul
    Physical contacts of bacteria and phage genomes allow in situ exploration of underdocumented phage families in the gut.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants

    Alon Avraham Ginatt, Maria Berihu ... Shiri Freilich
    Understanding metabolic interactions and successive cross-feeding in native microbiomes illuminates the mechanisms behind plant disease promotion and suppression, enhancing our ability to manipulate microbiomes toward specific functions of interest.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Global biogeographic sampling of bacterial secondary metabolism

    Zachary Charlop-Powers, Jeremy G Owen ... Sean F Brady
    Pyro-sequencing of two genes involved in bacterial secondary metabolism provides new insights into the rich reservoir of biologically active small molecules found in environmental bacteria.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A genome-phenome association study in native microbiomes identifies a mechanism for cytosine modification in DNA and RNA

    Weiwei Yang, Yu-Cheng Lin ... Laurence Ettwiller
    A novel DNA/RNA modifying enzyme catalyzing a previously unknown 5-carbamoyloxymethylcytosine modification has been discovered using a novel framework called Metagenomics Genome-Phenome Association.