1,043 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers

    Jessica E Scholey et al.
    The Bipolar Assembly domain of kinesin-5 comprises an anti-parallel four-helix bundle, which explains how kinesin-5 subunits assemble into bipolar tetramers with two motile ends that transmit forces while crosslinking and sliding adjacent microtubules during mitosis.
    1. Cell Biology

    Kinesin-6 regulates cell-size-dependent spindle elongation velocity to keep mitosis duration constant in fission yeast

    Lara Katharina Krüger et al.
    The scaling of spindle elongation velocity with cell size is regulated by the amounts of Kinesin-6 molecules and the number of binding sites for the motor to the mitotic spindle.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice

    Mina L Kojima et al.
    The switch from mitotic cell cycles to the one meiotic cell cycle in each generation is triggered through dramatic upregulation of a broad gene expression program by transcriptional regulator STRA8.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

    Nicolas Altemose et al.
    In humans, specific sequence features can predict whether meiotic recombination occurs at sites bound by the protein PRDM9, whose DNA-binding zinc-finger domain can unexpectedly bind to gene promoters and to other copies of PRDM9.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

    Tatyana Bodrug et al.
    Biochemical, single molecule, cell and structural biology studies reveal an interaction between the kinesin-5 tail and motor domains regulating high-force production, which is critical for microtubule sliding motility.
    1. Genetics and Genomics
    2. Plant Biology

    The genomic landscape of meiotic crossovers and gene conversions in Arabidopsis thaliana

    Erik Wijnker et al.
    A comprehensive and genome-wide description of the genomic make-up and frequency of meiotic recombination in Arabidopsis thaliana reveals regional preferences, including nucleosome-free regions, and two associated recombination motifs.
    1. Cell Biology
    2. Developmental Biology

    SUMO is a pervasive regulator of meiosis

    Nikhil R Bhagwat et al.
    Multi-dimensional global proteomics describes the SUMO-modified proteome during meiosis and reveals novel roles in regulating the key events of meiotic chromosome metabolism.
    1. Microbiology and Infectious Disease

    A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

    Aurélia C Balestra et al.
    Multiple steps of the atypical cell cycles underlying Plasmodium gametogony are controlled by a divergent cyclin/cyclin-dependent complex.
    1. Neuroscience

    Non-selective inhibition of inappropriate motor-tendencies during response-conflict by a fronto-subthalamic mechanism

    Jan R Wessel et al.
    Action-selection under response-conflict is buttressed by an inhibitory control signal from the basal ganglia that non-selectively suppresses motor excitability.
    1. Stem Cells and Regenerative Medicine

    Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model

    Hyunah Lee et al.
    Sequential introduction of transcription factors enables large-scale generation of induced motor neurons (iMNs) from human somatic cells, and transplantation of iMNs exhibit therapeutic effects in spinal cord injury model.

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