1,329 results found
    1. Chromosomes and Gene Expression

    High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast

    Yi Yin et al.
    Genome-wide mapping of heteroduplex DNA (a recombination intermediate) formed during mitotic recombination in yeast demonstrates that the "classical" model of double-strand DNA break repair is inadequate to explain several aspects of mitotic recombination.
    1. Genetics and Genomics

    Recombination, meiotic expression and human codon usage

    Fanny Pouyet et al.
    Variation in codon usage among functional categories of human genes is not due to selection for translation efficiency, but to differences in intragenic recombination rate, linked to variation in meiotic transcription level.
    1. Developmental Biology
    2. Genetics and Genomics

    Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice

    Mohamed Mahgoub et al.
    The meiotic recombination landscape in vertebrates was re-engineered via the co-evolution of a dual histone H3K4/H3K36 methylation 'writer' PRDM9 and its 'reader' ZCWPW1 that facilitates efficient double strand break repair.
    1. Cell Biology

    A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1

    Natalia Felipe-Medina et al.
    Genetic and biochemical analysis reveal a variant in HSF2BP causing POI and C19ORF57/BRME1 as an interactor and stabilizer of HSF2BP by forming a complex with BRCA2, RAD51, RPA and PALB2.
    1. Chromosomes and Gene Expression

    Local chromosome context is a major determinant of crossover pathway biochemistry during budding yeast meiosis

    Darpan Medhi et al.
    Different homologous recombination pathways are dominant in different regions of meiotic chromosomes, indicating that chromosome structure influences recombination biochemistry.
    1. Chromosomes and Gene Expression

    The kinetochore prevents centromere-proximal crossover recombination during meiosis

    Nadine Vincenten et al.
    The meiotic DNA recombination landscape is locally influenced by the kinetochore to minimize potentially deleterious pericentromeric crossover recombination.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Vilya, a component of the recombination nodule, is required for meiotic double-strand break formation in Drosophila

    Cathleen M Lake et al.
    The Zip3-like protein Vilya links the initiation of meiotic recombination with crossover formation.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The synaptonemal complex has liquid crystalline properties and spatially regulates meiotic recombination factors

    Ofer Rog et al.
    Formation of a phase-separated interface between homologous chromosomes during meiosis enables regulatory signals to spread in cis over long distances, illuminating the longstanding mystery of crossover interference.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    ATR/Mec1 prevents lethal meiotic recombination initiation on partially replicated chromosomes in budding yeast

    Hannah G Blitzblau, Andreas Hochwagen
    During meiosis, budding yeast use a checkpoint involving the protein Mec1 to prevent the formation of double-strand breaks in DNA that has not completed replication.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

    Nicolas Altemose et al.
    In humans, specific sequence features can predict whether meiotic recombination occurs at sites bound by the protein PRDM9, whose DNA-binding zinc-finger domain can unexpectedly bind to gene promoters and to other copies of PRDM9.

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