1,123 results found
    1. Cell Biology
    2. Developmental Biology

    Mitotic spindle scaling during Xenopus development by kif2a and importin α

    Jeremy D Wilbur, Rebecca Heald
    An interaction between two proteins enables the spindle—the structure that segregates chromosome pairs during mitosis—to change size as cells divide.
    1. Cell Biology
    2. Developmental Biology

    Optogenetic dissection of mitotic spindle positioning in vivo

    Lars-Eric Fielmich et al.
    New germline gene expression, knockout, and optogenetic tools reveal essential roles for Gα-GPR-1,2/Pins as a regulatable membrane anchor and LIN-5/NuMA as an activator of cortical dynein in mitotic spindle positioning.
    1. Cell Biology

    Kinesin-6 regulates cell-size-dependent spindle elongation velocity to keep mitosis duration constant in fission yeast

    Lara Katharina Krüger et al.
    The scaling of spindle elongation velocity with cell size is regulated by the amounts of Kinesin-6 molecules and the number of binding sites for the motor to the mitotic spindle.
    1. Cell Biology

    Spatial signals link exit from mitosis to spindle position

    Jill Elaine Falk et al.
    In yeast, exit from mitosis is triggered by the movement of one spindle pole body out of the mother cell into the bud, the future daughter cell.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

    Heidi Hehnly et al.
    A protein kinase complex that is important for cell division is lost in testicular seminoma, which is a common cancer in men.
    1. Physics of Living Systems
    2. Cell Biology

    27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells

    Lei Zhang et al.
    An ultra-high static magnetic field changes mitotic spindle orientation in cells by exerting magnetic torques on both microtubules and chromosomes.
    1. Cell Biology

    The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle

    Faye M Nixon et al.
    Microtubules of mitotic spindle fibers are positioned and held together by a meshwork of multipolar connectors.
    1. Cell Biology

    The Mitotic Exit Network integrates temporal and spatial signals by distributing regulation across multiple components

    Ian Winsten Campbell et al.
    By distributing regulation to both the GTPase and downstream kinases, the Mitotic Exit Network creates a single signal from spatial and temporal inputs.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Kinesin-12 Kif15 is a processive track-switching tetramer

    Hauke Drechsler et al.
    The first in vitro analysis of full-length human Kif15 provides insight into how hKif15 and its inhibitory binding partner hTpx2 modulate mitotic spindle architecture.

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