In vivo study of arbovirus infections reveals the dominant role of pDC IRF7-signaling in directing both type I and II IFN responses, and leading to viral control.
A set of sexually dimorphic neurons in female flies is part of a recurrent neural network and drives minutes-long persistent neural activity and persistent social behaviors.
Yael Mandelblat-Cerf, Rohan N Ramesh ... Mark L Andermann
Gradual changes in the firing of specific hypothalamic neurons over many hours signal falling energy levels, while short-lived changes over seconds and minutes signal the availability of food.
Matthew J Sternfeld, Christopher A Hinckley ... Samuel L Pfaff
Stem cell derived ventral-spinal cord excitatory neurons self-assemble into a rhythmically bursting neural network whose speed and intercellular coordination are both instructively modulated by cell-type specific interactions with inhibitory neurons.
Ariane C Boehm, Anja B Friedrich ... Ilona C Grunwald Kadow
Behavioral and in vivo imaging analysis in the fly suggests that mating-related sensory experience regulates female odor perception and expression of choice behavior through a dopamine-gated learning circuit.
Jonathan M Stokes, Joseph H Davis ... Eric D Brown
The anticonvulsant drug lamotrigine inhibits bacterial ribosome biogenesis and reveals an unexplored role for initiation factor 2 (IF2) in ribosome assembly.
For the same bacterial strain, the swarming phenotype can be biophysically discerned from swimming phenotype based on the motion pattern under circular confinement on a soft agar.
Two non-overlapping neural circuits that involve the lamina terminalis and arcuate nucleus of hypothalamus independently drive feedforward anticipatory suppression and activation of vasopressin neurons by drinking and feeding, respectively.