34 results found
    1. Immunology and Inflammation

    Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses

    Brian Webster, Scott W Werneke ... Marlène Dreux
    In vivo study of arbovirus infections reveals the dominant role of pDC IRF7-signaling in directing both type I and II IFN responses, and leading to viral control.
    1. Neuroscience

    The neural basis for a persistent internal state in Drosophila females

    David Deutsch, Diego Pacheco ... Mala Murthy
    A set of sexually dimorphic neurons in female flies is part of a recurrent neural network and drives minutes-long persistent neural activity and persistent social behaviors.
    1. Neuroscience

    Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales

    Yael Mandelblat-Cerf, Rohan N Ramesh ... Mark L Andermann
    Gradual changes in the firing of specific hypothalamic neurons over many hours signal falling energy levels, while short-lived changes over seconds and minutes signal the availability of food.
    1. Cell Biology
    2. Neuroscience

    Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells

    Matthew J Sternfeld, Christopher A Hinckley ... Samuel L Pfaff
    Stem cell derived ventral-spinal cord excitatory neurons self-assemble into a rhythmically bursting neural network whose speed and intercellular coordination are both instructively modulated by cell-type specific interactions with inhibitory neurons.
    1. Neuroscience

    Global change in brain state during spontaneous and forced walk in Drosophila is composed of combined activity patterns of different neuron classes

    Sophie Aimon, Karen Y Cheng ... Ilona C Grunwald Kadow
    Major neuron classes are activated when the fly walks, whether it chooses or is forced to do so.
    1. Neuroscience

    A dopamine-gated learning circuit underpins reproductive state-dependent odor preference in Drosophila females

    Ariane C Boehm, Anja B Friedrich ... Ilona C Grunwald Kadow
    Behavioral and in vivo imaging analysis in the fly suggests that mating-related sensory experience regulates female odor perception and expression of choice behavior through a dopamine-gated learning circuit.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Discovery of a small molecule that inhibits bacterial ribosome biogenesis

    Jonathan M Stokes, Joseph H Davis ... Eric D Brown
    The anticonvulsant drug lamotrigine inhibits bacterial ribosome biogenesis and reveals an unexplored role for initiation factor 2 (IF2) in ribosome assembly.
    1. Physics of Living Systems

    Confinement discerns swarmers from planktonic bacteria

    Weijie Chen, Neha Mani ... Jay X Tang
    For the same bacterial strain, the swarming phenotype can be biophysically discerned from swimming phenotype based on the motion pattern under circular confinement on a soft agar.
    1. Medicine
    2. Neuroscience

    Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality

    Angela Kim, Joseph C Madara ... Bradford B Lowell
    Two non-overlapping neural circuits that involve the lamina terminalis and arcuate nucleus of hypothalamus independently drive feedforward anticipatory suppression and activation of vasopressin neurons by drinking and feeding, respectively.

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