3,887 results found
    1. Neuroscience

    NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive inhibition in the mouse hippocampus

    Andrea L Hartzell et al.
    Behaviorally-driven expression of the immediate early gene transcription factor NPAS4 changes local circuit connectivity and short-term plasticity by selectively recruiting CCK basket cell synapses to pyramidal neuron somas.
    1. Neuroscience

    Neuronal Plasticity: Genetic signatures of memories

    Vivek Sagar, Thorsten Kahnt
    Memorable positive and negative experiences produce different profiles of gene expression in the brain areas associated with long-term memory.
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    1. Neuroscience

    Alzheimer’s Disease: Identifying faulty brain circuits

    Jesse E Hanson
    A protein called NPTX2 may be a useful marker of neural circuit defects in patients with Alzheimer's disease.
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    1. Neuroscience

    NPTX2 and cognitive dysfunction in Alzheimer’s Disease

    Mei-Fang Xiao et al.
    Dysfunction of pyramidal neuron-PV interneuron circuits contributes to cognitive failure in Alzheimer's disease.
    1. Neuroscience

    Salient experiences are represented by unique transcriptional signatures in the mouse brain

    Diptendu Mukherjee et al.
    Inducible transcription in the brain encodes detailed aspects of recent experience.
    1. Neuroscience

    A robust activity marking system for exploring active neuronal ensembles

    Andreas T Sørensen et al.
    A new system for tagging activated neuronal population offers multiple advantages over existing systems based on immediate early genes, including greater sensitivity and specificity, and suitability for easy application in species other than mice.
    1. Developmental Biology

    MicroRNA-934 is a novel primate-specific small non-coding RNA with neurogenic function during early development

    Kanella Prodromidou et al.
    Primate-specific miR-934 mediates neurogenesis and downstream neuronal differentiation processes, modulating the expression of genes associated with the subplate, a region most prominent in primates, emerging during early cortical development.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program

    Madara Ratnadiwakara et al.
    RNA-binding protein SRSF3 mediates critical changes in RNA processing of pluripotency genes, which reveals functional consequences of regulated RNA processing during stem cell self-renewal and early development.
    1. Developmental Biology
    2. Evolutionary Biology

    Multicellularity: The evolution of gene regulation

    Veronica Hinman, Gregory Cary
    The gene regulation mechanisms necessary for the development of complex multicellular animals have been found in sponges.
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    1. Human Biology and Medicine
    2. Neuroscience

    Tissue Engineering: Building a better blood-brain barrier

    Courtney Lane-Donovan, Joachim Herz
    A new three-dimensional model of the blood-brain barrier can be used to study processes that are involved in neurodegenerative diseases.
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