323 results found
    1. Neuroscience

    Neuropathological and transcriptomic characteristics of the aged brain

    Jeremy A Miller et al.
    High variability in neuropathology burden and interactions between dementia diagnosis and RNA quality present underappreciated complications when studying dementia in an aged population.
    1. Biochemistry and Chemical Biology

    Rational design of aptazyme riboswitches for efficient control of gene expression in mammalian cells

    Guocai Zhong et al.
    An empirically derived scoring system for identifying optimal communication modules of aptazymes accelerates the development of ligand-responsive RNA genetic switches functional in mammalian cells.
    1. Neuroscience

    Learning precise spatiotemporal sequences via biophysically realistic learning rules in a modular, spiking network

    Ian Cone, Harel Z Shouval
    A computational model shows that it's possible to learn and replay extended temporal sequences in a network of spiking neurons with a modular architecture and a biologically realistic learning rule.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

    Tingting Wang et al.
    The transcription factor (TF)-binding specificities of Pseudomonas aeruginosa allow us to predict virulence-associated TFs and their target genes, which will facilitate to find effective treatment and prevention for its associated diseases.
    1. Computational and Systems Biology
    2. Developmental Biology

    High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals

    Luciano Marcon et al.
    Realistic reaction-diffusion signaling networks that include cell-autonomous factors can robustly form self-organizing spatial patterns for any combination of diffusion coefficients without requiring differential diffusivity.
    1. Neuroscience

    Learning place cells, grid cells and invariances with excitatory and inhibitory plasticity

    Simon Nikolaus Weber, Henning Sprekeler
    A large variety of spatial representations implied in rodent navigation could arise robustly and rapidly from inputs with a weak spatial structure, by an interaction of excitatory and inhibitory synaptic plasticity.
    1. Cell Biology

    Mapping the dynamics of force transduction at cell–cell junctions of epithelial clusters

    Mei Rosa Ng et al.
    The integrated quantification of spontaneous dynamic cell-cell force transmissions at both multi-cellular and subcellular scales enables spatiotemporal correlations of stress distribution with biomolecules in small cell clusters.
    1. Ecology
    2. Computational and Systems Biology

    A locally-blazed ant trail achieves efficient collective navigation despite limited information

    Ehud Fonio et al.
    Ants employ a new kind of trail to resolve group-level navigational difficulties in scenarios where the information available to individuals does not suffice.
    1. Computational and Systems Biology

    Point of View: Data science for the scientific life cycle

    Daphne Ezer, Kirstie Whitaker
    Each stage of the scientific life cycle stands to benefit from the introduction of data science techniques.
  1. Meta-Research: A retrospective analysis of the peer review of more than 75,000 Marie Curie proposals between 2007 and 2018

    David G Pina et al.
    A study of more than 75,000 grant proposals to the European Union indicates that the outcomes of the peer review process remain stable in response to changes in the way that peer review is organized.

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