7,635 results found
    1. Neuroscience

    A flexible framework for simulating and fitting generalized drift-diffusion models

    Maxwell Shinn et al.
    Sophisticated decision-making mechanisms and complex experimental paradigms can be modeled, simulated, and fit to empirical response time data, using a flexible and efficient computational modeling framework.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Earliest infections predict the age distribution of seasonal influenza A cases

    Philip Arevalo et al.
    First influenza infections determine susceptibility to future seasonal influenza infection throughout life, and may impact vaccine effectiveness.
    1. Neuroscience

    Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model

    Jingheng Cheng, Daoyun Ji
    In a mouse model of neurodegeneration, hippocampal firing sequences that normally encode spatial memories become disengaged from external space.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection

    Pengxing Cao et al.
    A mathematical model of blood-stage infection with Plasmodium falciparum malaria capturing the sexual stage of the parasite life-cycle is validated against human data, providing new insight into human-to-mosquito transmission.
    1. Computational and Systems Biology
    2. Neuroscience

    Noise promotes independent control of gamma oscillations and grid firing within recurrent attractor networks

    Lukas Solanka et al.
    Random fluctuations in neuronal firing may enable a single brain region, the medial entorhinal cortex, to perform distinct roles in cognition (by generating gamma waves) and spatial navigation (by producing a grid cell map).
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Molecular dynamics-based refinement and validation for sub-5 Å cryo-electron microscopy maps

    Abhishek Singharoy et al.
    New hybrid structure determination methods leveraging the inherent biophysical properties of a macromolecule through molecular dynamics simulations provide accurate and cost-efficient ways of achieving atomic structures from high resolution cryo-electron density maps.
    1. Computational and Systems Biology
    2. Neuroscience

    Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit

    Marianne J Bezaire et al.
    Spontaneous theta oscillations and interneuron-specific phase preferences emerge spontaneously in a full-scale model of the isolated hippocampal CA1 subfield, corroborating and extending recent experimental findings.
    1. Neuroscience

    Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making

    Karima Chakroun et al.
    Dopamine attenuates exploration during decision-making via a reduction of neural tracking of uncertainty.
    1. Neuroscience

    A resource-rational theory of set size effects in human visual working memory

    Ronald van den Berg, Wei Ji Ma
    Set size effects in visual working memory are explained as a resource-rational trade-off between an error-based behavioral cost and a neural encoding cost.
    1. Neuroscience

    Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors

    Daine R Lesniak et al.
    Computer simulations show that the firing patterns of branched touch receptors can be set in part by the organization of their sensory endings in the skin.

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