Neural activity in the orbitofrontal cortex (OFC) represents incidental stimulus-stimulus associations, providing additional evidence for OFC having a role in cognition beyond functions centered on processing value or biological significance.
The conductance-based encoding model creates a new bridge between statistical models and biophysical models of neurons, and infers visually-evoked excitatory and inhibitory synaptic conductances from spike trains in macaque retina.
Embryo-wide quantitative analysis of BMP signaling in zebrafish embryos, combined with a mathematical model-based computational screen, challenges the prevailing model of an antagonist counter-gradient shaping the gastrula BMP morphogen gradient and supports an antagonist sink with BMP diffusion mechanism.
Loss and gain-of-function investigation uncovers a regulatory network controlling human heart chamber specification in which the cardiac precursor gene ISL1 accelerates ventricular induction and antagonizes retinoic acid-driven atrial commitment.
Specification and expansion during rib development is explained by Agent-Based Modeling while respecting the locality of decision-making that occurs as millions of cells coordinate their behavior to form and refine spatial pattern.