Dorsomedial D2-MSNs and D1-MSNs exhibit opposing dynamics during interval timing, however disrupting either MSN type produces similar effects on behavior, highlighting the complementary roles of striatal pathways in cognitive operations.

Aneuploid human embryonic cells are eliminated by p53-mediated apoptosis in a gene dosage dependent manner.

Innovative JAGGED1-based therapies show promise for pediatric craniofacial bone loss, potentially overcoming limitations of current treatments with more effective and accessible solutions.

The utility of an in vitro cell culture system for studies of molecular mechanisms underlying the initial induction and subsequent propagation of environmentally induced epimutations is demonstrated.

Regulatory T cells produce analgesic opioid peptides that limit heat sensitivity in mice, revealing a novel pain regulation mechanism independent of inflammation control.

There is a significant disadvantage to receive a major grant (i.e., R01) for K99/R00 awardees that are women, those at lower funded institutions, and those with lower career mobility.

Increased genetic liability to colorectal cancer is associated with altered levels of circulating metabolites, including fatty acids, up to 40 years before average age of diagnosis.

In late 2021 and early 2022, many clinicians in Federally Qualified Health Centers (FQHCs) reported reduced cervical cancer screening and reported that pandemic-related staffing shortages impacted screening and follow-up.

Ex vivo, in vitro, and computational modeling studies indicate a persistence of myofibroblast senescence in the infarct border zone with age which can disrupt conduction and promote arrhythmias via senescent myofibroblast-cardiomyocyte coupling.