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    1. Genetics and Genomics
    2. Neuroscience

    Learning is enhanced by tailoring instruction to individual genetic differences

    David G Mets, Michael S Brainard
    Tailoring instructive experience to individual genetic biases improves vocal learning outcomes across genetic backgrounds in the Bengalese finch.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Predicting geographic location from genetic variation with deep neural networks

    CJ Battey, Peter L Ralph, Andrew D Kern
    Neural networks allow fast and accurate prediction of individual spatial locations from genotypes or sequencing data.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations

    Daniel M Parker, Sai Thein Than Tun ... François Nosten
    Given sufficient population adherence, mass drug administration for falciparum malaria can provide group level benefits, also known as ‘herd effects’.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Association mapping from sequencing reads using k-mers

    Atif Rahman, Ingileif Hallgrímsdóttir ... Lior Pachter
    Associations can be mapped using k-mer frequencies in sequencing reads without prior sequencing of a reference genome enabling detection of associations to variants of multiple types and outside of the reference.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Genetic variation in ALDH4A1 is associated with muscle health over the lifespan and across species

    Osvaldo Villa, Nicole L Stuhr ... Sean P Curran
    Leveraging the US Health and Retirement Study and C. elegans genetics reveals ALDH4A1/alh-6 as an evolutionarily conserved biomarker for normal muscle function over the lifespan.
    1. Cell Biology
    2. Neuroscience

    Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones

    Chao Tan, Giovanni de Nola ... Pascal S Kaeser
    Hextuple knockout of key active zone proteins strongly reduces the pool of synaptic vesicles available for release, but synapse formation persists.
    1. Epidemiology and Global Health
    2. Medicine

    The impact of measles immunization campaigns in India using a nationally representative sample of 27,000 child deaths

    Benjamin KC Wong, Shaza A Fadel ... Prabhat Jha
    Measles immunization campaigns in India accelerated declines in child measles mortality rates and averted 41,000-56,000 child measles deaths during 2010 to 2013.
    1. Medicine
    2. Neuroscience

    Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study

    Peter R Millar, Brian A Gordon ... Beau M Ances
    Machine learning-based models of brain age using distinct MRI modalities (structural MRI and functional connectivity) capture complementary signals related to healthy age differences and capture unique patterns related to Alzheimer disease, including stages of disease progression, biomarkers, and cognition.
    1. Neuroscience

    Complementary cognitive roles for D2-MSNs and D1-MSNs during interval timing

    Robert A Bruce, Matthew Weber ... Kumar Narayanan
    Dorsomedial D2-MSNs and D1-MSNs exhibit opposing dynamics during interval timing, however disrupting either MSN type produces similar effects on behavior, highlighting the complementary roles of striatal pathways in cognitive operations.
    1. Immunology and Inflammation

    IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis

    Qian Wang, Christin M Lepus ... William H Robinson
    Osteoarthritis pathogenesis is driven by IgE-mediated mast cell activation.