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    1. Computational and Systems Biology

    Calibration and analysis of genome-based models for microbial ecology

    Stilianos Louca, Michael Doebeli
    A novel computation tool for microbial community modeling predicts the evolution and diversification of E. coli in laboratory evolution experiments and gives insight into the underlying metabolic processes.
    1. Structural Biology and Molecular Biophysics

    Model-based local density sharpening of cryo-EM maps

    Arjen J Jakobi et al.
    Local sharpening of cryo-electron microscopy maps using atomic models can increase the interpretability of densities in cases of resolution variation and facilitates model building and refinement.
    1. Neuroscience

    Metacontrol of decision-making strategies in human aging

    Florian Bolenz et al.
    Older adults show reduced adaptation of decision-making strategies to dynamically changing situational demands.
    1. Computational and Systems Biology
    2. Developmental Biology

    Retinal stem cells modulate proliferative parameters to coordinate post-embryonic morphogenesis in the eye of fish

    Erika Tsingos et al.
    3D niche topology imposes a spatially biased random stem cell loss, which is differentially fine-tuned in neural retina and retinal pigmented epithelium to regulate growth, shape, and cellular topology.
    1. Medicine
    2. Microbiology and Infectious Disease

    Early prediction of level-of-care requirements in patients with COVID-19

    Boran Hao et al.
    Using data for 2566 COVID-19 patients from five hospitals, models are developed to predict for each patient hospitalization and critical care needs, based on demographics, comorbidities, medications, and laboratory findings.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Integrating between-host transmission and within-host immunity to analyze the impact of varicella vaccination on zoster

    Benson Ogunjimi et al.
    An individual-based model estimates exogenous boosting of immunity following re-exposure to chickenpox is limited to 2 years after re-exposure, but an increase in herpes zoster incidence is still expected to occur following universal varicella vaccination.
    1. Neuroscience

    Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory

    Paul Pfeiffer et al.
    Independently gating ion channels typically act fast within milliseconds, but cooperative interactions within a cluster of channels allow for a memory of previous electrical activity for several seconds.
    1. Neuroscience

    Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action

    Jennifer C Swart et al.
    Motivational coupling of action to reward and inhibition to punishment is subserved by dissociable learning and choice processes, and is modulated by dopamine/noradrenaline transporter blockade.
    1. Neuroscience

    A compositional neural code in high-level visual cortex can explain jumbled word reading

    Aakash Agrawal et al.
    Viewing a jumbled word activates an efficient visual representation in high-level visual cortex that is matched to stored words in the word form area.
    1. Neuroscience

    Associability-modulated loss learning is increased in posttraumatic stress disorder

    Vanessa M Brown et al.
    Veterans with PTSD show increased attention to a history of unexpected outcomes during loss learning, both as measured by computational model-derived behavioral parameters and in increased neural signaling in amygdala and insula.