8,142 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Model discovery to link neural activity to behavioral tasks

    Jamie D Costabile, Kaarthik A Balakrishnan ... Martin Haesemeyer
    Model identification of neural encoding is an accessible system for the analysis of neural data that allows identifying and characterizing arbitrary relationships between neural activity and task-related variables such as behavior, stimuli, or internal states.
    1. Ecology
    2. Epidemiology and Global Health

    Predictors of human-infective RNA virus discovery in the United States, China, and Africa, an ecological study

    Feifei Zhang, Margo Chase-Topping ... Mark EJ Woolhouse
    In three different regions including the United States, China, and Africa, virus discoveries were strongly associated with GDP and land use, but were less likely to be associated with climate and biodiversity variables than at a global scale.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Lipid discovery enabled by sequence statistics and machine learning

    Priya M Christensen, Jonathan Martin ... Kelli L Palmer
    A previously unknown lipid modification by a bacterial antibiotic resistance enzyme was identified through the analysis of a family of antibiotic resistance enzyme sequences with a machine learning approach.
    1. Cell Biology
    2. Developmental Biology

    Discovery of novel determinants of endothelial lineage using chimeric heterokaryons

    Wing Tak Wong, Gianfranco Matrone ... John P Cooke
    Bioinformatic analysis of gene expression in chimeric heterokaryons can identify novel regulators of cell lineage.
    1. Computational and Systems Biology

    Applying causal discovery to single-cell analyses using CausalCell

    Yujian Wen, Jielong Huang ... Hao Zhu
    Based on benchmarking various methods and analyzing multiple real scRNA-seq datasets, a computational platform/workflow and a set of tips for best practices are developed for analyzing causal interactions or relationships in single cells.
    1. Neuroscience

    Accelerating with FlyBrainLab the discovery of the functional logic of the Drosophila brain in the connectomic and synaptomic era

    Aurel A Lazar, Tingkai Liu ... Yiyin Zhou
    FlyBrainLab is an open-source computing platform that integrates 3D exploration and visualization of diverse Drosophila connectomic/synaptomic datasets with interactive exploration of the functional logic of modeled executable brain circuits.
    1. Biochemistry and Chemical Biology

    The ‘ForensOMICS’ approach for postmortem interval estimation from human bone by integrating metabolomics, lipidomics, and proteomics

    Andrea Bonicelli, Hayley L Mickleburgh ... Noemi Procopio
    The integration of multiple omics panels obtained from bone tissue could aid in the evaluation of the postmortem interval in forensic investigations, expanding the boundaries of forensic research.
    1. Microbiology and Infectious Disease

    A novel lineage-tracing mouse model for studying early MmuPV1 infections

    Vural Yilmaz, Panayiota Louca ... Katerina Strati
    A novel mouse model which permits tracking of papillomavirus infected cells in mouse stratified epithelia during early infection by means of genetic reporter activation.
    1. Physics of Living Systems

    Deciphering the regulatory genome of Escherichia coli, one hundred promoters at a time

    William T Ireland, Suzannah M Beeler ... Rob Phillips
    A combination of massively parallel reporter assays and mass spectrometry uncovers the regulation of previously unexplored promoters across the Escherichia coli genome.
    1. Computational and Systems Biology

    A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates

    Dennis Wang, James Hensman ... Frank Dondelinger
    Quantification of uncertainty in drug dose-responses provides a more robust metric for differentiating drugs and identifying biomarkers of response.

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