4,552 results found
  1. Episode 45: February 2018

    In this episode, we hear about disease control in insects, placental development, post-traumatic stress disorder, the mission to create a human cell atlas and how crickets amplify their song.
    1. Neuroscience

    Reconstruction of natural images from responses of primate retinal ganglion cells

    Nora Brackbill et al.
    The visual message conveyed by retinal neurons to the brain when signaling natural scenes resembles the individual receptive fields only when viewed in context of the neuronal population.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

    Xiao Ling Li et al.
    Discovery and initial characterization of a conserved small protein translated from a transcript annotated as a human long non-coding RNA.
    1. Neuroscience

    Social dominance mediates behavioral adaptation to chronic stress in a sex-specific manner

    Stoyo Karamihalev et al.
    Social dominance has opposing effects on behavior following stress in male vs. female mice indicating an important role in sex differences in the stress response.
    1. Immunology and Inflammation

    Peripheral natural killer cells in chronic hepatitis B patients display multiple molecular features of T cell exhaustion

    Marie Marotel et al.
    Similar to T cell exhaustion, natural killer cell dysfunction in chronic hepatitis B patients results from deregulated calcium pathway.
    1. Evolutionary Biology

    Constitutive activation of cellular immunity underlies the evolution of resistance to infection in Drosophila

    Alexandre B Leitão et al.
    Single-cell transcriptomics of immune cells demonstrates that populations evolve inducible defences when infection rates are low and constitutive defences when infection is common.
    1. Neuroscience

    Canonical goal-selective representations are absent from prefrontal cortex in a spatial working memory task requiring behavioral flexibility

    Claudia Böhm, Albert K Lee
    Representation of goals in the forms previously reported in the PFC is not required for performance of a novel spatial working memory task where goal information must be used flexibly.
    1. Stem Cells and Regenerative Medicine

    Sequential activation of transcriptional repressors promotes progenitor commitment by silencing stem cell identity genes

    Noemi Rives-Quinto et al.
    Silencing of stem cell identity genes during progenitor commitment ensures that intermediate progenitors robustly commit to generate differentiated cell types rather than abnormal stem-cell-like cells during indirect neurogenesis.
    1. Cell Biology
    2. Developmental Biology

    Coordinated crosstalk between microtubules and actin by a spectraplakin regulates lumen formation and branching

    Delia Ricolo, Sofia J Araujo
    Lumen formation by single epithelial cells depends on FGF-signalling-dependent expression of a spectraplakin, which can be functionally replaced by Tau.
    1. Neuroscience

    The actin-modulating protein synaptopodin mediates long-term survival of dendritic spines

    Kenrick Yap et al.
    Long-term imaging of dentate granule cells reveals that the presence of synaptopodin within large spines, rather than their size, conveys long-term stability to large spines.

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