4,203 results found
    1. Biochemistry and Chemical Biology

    Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis

    Byungchul Kim et al.
    Enterococci faecium encodes unique peptidoglycan composition and remodeling activity that activates host immunity.
    1. Structural Biology and Molecular Biophysics

    Structural and functional characterization of an otopetrin family proton channel

    Qingfeng Chen et al.
    Structural and functional analysis of the OTOP3 channel from Xenopus tropicalis offers insights into the mechanism of ion transport and regulation in the otopetrin proton channel family.
    1. Cancer Biology
    2. Immunology and Inflammation

    NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte

    SM Nashir Udden et al.
    NOD-like receptor NLRP12 is a critical regulator of hepatocyte proliferation and its activation could be therapeutically used to suppress hepatocellular carcinoma.
    1. Plant Biology

    Decoys provide a scalable platform for the identification of plant E3 ubiquitin ligases that regulate circadian function

    Ann Feke et al.
    The F-box and U-box E3 ubiquitin ligase decoy library is a powerful tool for the functional characterization of redundant E3 ubiquitin ligases, like MAC3A and MAC3B, novel circadian clock regulators.
    1. Neuroscience

    Empirical examination of the replicability of associations between brain structure and psychological variables

    Shahrzad Kharabian Masouleh et al.
    Empirical evaluations demonstrate the low probability of finding and replicating significant associations between psychological tests and brain structure in healthy adults, highlighting the importance out-of-sample replication of exploratory findings.
    1. Chromosomes and Gene Expression

    Reporter-ChIP-nexus reveals strong contribution of the Drosophila initiator sequence to RNA polymerase pausing

    Wanqing Shao et al.
    Reporter-ChIP-nexus captures paused Pol II on transfected plasmids and shows that pausing stability is influenced by core promoter sequences, especially by the initiator with a G at +2 position.
    1. Developmental Biology

    Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

    Fabienne Benz et al.
    Endothelial tightening by augmenting low level Wnt/β-catenin activity in vessels of the mouse subfornical organ, influences neuronal activation in water-deprived mice, linking endothelial barrier properties to neuro-vascular coupling.
    1. Structural Biology and Molecular Biophysics

    Binding and transport of D-aspartate by the glutamate transporter homolog GltTk

    Valentina Arkhipova et al.
    Glutamate transporter homologs can efficiently bind and transport both L- and D- enantiomeric substrates with only slight rearrangements in the binding site.

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