Molecular beacon based FISH shows the capability of visualizing a 2.5 kb non-repetitive genomic DNA sequence in situ in human or mouse nuclear genome at super resolution.

The small molecule EMD 57033 is one of a new class of pharmacological chaperones that stabilize, enhance the activity of, and correct stress-induced misfolding of myosin proteins.

Light signals adjusting the brain's daily clock induce distinct waveform changes in molecular clock gene rhythms at dawn and dusk, and trigger regionally differential clock changes.

A mutagenesis screen in budding yeast sheds light on dynein regulation and function, and reveals the molecular basis for disease in patients suffering from neuropathies caused by dynein dysfunction.

A gradual, step-wise, physiological/molecular response of eyespot size to temperature is a likely adaptation to seasonal variation experienced in the habitat of Bicyclusanynana butterflies.

Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.

Experimentally evolved yeast populations increase in fitness predictably but do not divide into coexisting lineages or dramatically increase their mutation rates after 10,000 generations.

During stress conditions, eukaryotic cells dramatically alter their biophysical properties to regulate diffusion of macromolecules.

Single-cell transcriptomics correlated with in situ gene expression analysis provide an overview of the diversity and molecular features of cell types in the squid Loligo vulgaris.

Evidence for a largely unexplored radiation of squamates (lizards, snakes, and amphisbaenians) in the Middle to Late Jurassic is revealed by analyses of morphospace expansion, disparity, and evolutionary rates.