Davis Laundon, Nathan Chrismas ... Michael Cunliffe
Three-dimensional cell modelling, lipid analysis, transcriptomics, and live-cell imaging reveal biological insights in to the key stages of the chytrid fungus life cycle.
A network of the gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs and supports the generation of mechanistic hypotheses of microbiome metabolic phenotypes that shape human biology.
The Cohesin subunit Scc3 contains a hook-shaped domain that binds to DNA substrate, thus revealing that Cohesin-chromatin transactions are driven not only by topological interactions, but also by direct protein-DNA contacts.
Computational model reveals how the fast exchange of neurotransmitter receptors between synapses induces a competition leading to a transient form of heterosynaptic plasticity and shaping the induction of homosynaptic plasticity.
Formation of a phase-separated interface between homologous chromosomes during meiosis enables regulatory signals to spread in cis over long distances, illuminating the longstanding mystery of crossover interference.
Structural biology studies reveal the importance of protein dynamics on understanding molecular mechanisms underlying allosteric modulation of G protein-coupled receptors (GPCR) that offer insights into future GPCR research and drug discovery.
Sven Schenk, Stephanie C Bannister ... Kristin Tessmar-Raible
A molecular profiling approach to quantify transcripts and proteins from identical samples allows study of molecular effects of maturation, sexual differentiation and the endogenous circalunar clock in a marine worm.
Retinal visual response properties in awake mice are similar to those under anesthesia or ex vivo, but not exactly the same, so knowledge of retinal function cannot be simply translated from ex vivo to in vivo.
Cryo-EM structures of RNA polymerase I reveal considerable 'transformers-like' rearrangements where one subcomplex dissociates and is replaced by one domain of another subunit, possibly as an additional layer of transcriptional control.
