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    1. Structural Biology and Molecular Biophysics
    2. Biochemistry and Chemical Biology

    Structural mechanism of ligand activation in human calcium-sensing receptor

    Yong Geng, Lidia Mosyak ... Qing R Fan
    L-amino acids are agonists of calcium-sensing receptor, and act jointly with calcium and phosphate ions to control receptor function.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    High-throughput imaging and quantitative analysis uncovers the nature of plasmid positioning by ParABS

    Robin Köhler, Eugen Kaganovitch, Seán M Murray
    The ParABS system positions plasmids precisely within the cell but just below the threshold for oscillatory dynamics.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers

    Marco Molari, Klaus Eyer ... Rémi Monasson
    Detailed and inferred model reproduces B-cell affinity distributions measured in mice immunized according to various protocols and explains non-monotonous effects of antigen dosage on maturation.
    1. Developmental Biology

    Geometric models for robust encoding of dynamical information into embryonic patterns

    Laurent Jutras-Dubé, Ezzat El-Sherif, Paul François
    Propagation, speed and shapes of genetic waves of expression during development can be modeled by a simple interplay between two transcriptional modules (dynamic/static), which explains robustness and precision of patterning.
    1. Cell Biology
    2. Developmental Biology

    Decoding the IGF1 signaling gene regulatory network behind alveologenesis from a mouse model of bronchopulmonary dysplasia

    Feng Gao, Changgong Li ... Parviz Minoo
    Publicly available gene expression data and proven methodologies for building model Gene Regulatory Networks are applied to successfully construct the IGF1 signaling GRN behind alveologenesis, serving as a pioneer in transforming how lung development and its associated diseases is approached.
    1. Neuroscience

    Anatomy and activity patterns in a multifunctional motor neuron and its surrounding circuits

    Mária Ashaber, Yusuke Tomina ... Daniel A Wagenaar
    Voltage-dye imaging followed by serial blockface electron microscopy of the same ganglion reveals structure–function relationships of leech motor behaviors.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks

    Lance D Langston, Ryan Mayle ... Mike E O'Donnell
    Biochemical data demonstrate an unexpected and critical function for the enigmatic Mcm10 protein in helping the eukaryotic CMG helicase/replisome bypass roadblocks on the DNA that may also explain Mcm10 function at origins of replication.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A non-canonical mechanism for Crm1-export cargo complex assembly

    Ute Fischer, Nico Schäuble ... Vikram Govind Panse
    Slx9 is a newly discovered type of RanGTP-binding protein required for Crm1-mediated nuclear export.
    1. Cell Biology

    Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly

    Sari Tojkander, Gergana Gateva ... Pekka Lappalainen
    Mechanosensitive inhibition of actin polymerization through VASP phosphorylation is required for stress fiber maturation and alignment.
    1. Biochemistry and Chemical Biology

    Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

    Brent W Anderson, Kuanqing Liu ... Jue D Wang
    The signaling ligand (p)ppGpp regulates the enzyme HPRT across species by binding to a novel class of conserved motif, yet its specificity is allosterically altered through evolution of enzyme oligomerization.