7,508 results found
    1. Chromosomes and Gene Expression

    Super-resolution imaging of a 2.5 kb non-repetitive DNA in situ in the nuclear genome using molecular beacon probes

    Yanxiang Ni et al.
    Molecular beacon based FISH shows the capability of visualizing a 2.5 kb non-repetitive genomic DNA sequence in situ in human or mouse nuclear genome at super resolution.
    1. Structural Biology and Molecular Biophysics

    All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits

    Jodi A Hadden et al.
    All-atom molecular dynamics of the HBV capsid supports a role for structural asymmetry in biological function, reveals the potential for triangular pores to mediate cellular signaling, and indicates that capsid flexibility may limit resolution attainable by cryo-EM.
    1. Cell Biology
    2. Evolutionary Biology

    Evolution of an ancient protein function involved in organized multicellularity in animals

    Douglas P Anderson et al.
    Experimentally reconstructing the evolution of the molecular complex that animals use to orient the mitotic spindle establishes a simple genetic and physical mechanism for the emergence of a function essential for multicellularity.
    1. Evolutionary Biology
    2. Plant Biology

    Natural selection and repeated patterns of molecular evolution following allopatric divergence

    Yibo Dong et al.
    The genomic architecture of allopatric species is a mosaic of many conserved genes and a few adaptive ones, reflecting balance between conservation of ancestral functions and evolution of new features.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Integrating influenza antigenic dynamics with molecular evolution

    Trevor Bedford et al.
    Combined antigenic and genetic analysis shows that different strains of the human influenza virus display dramatically different rates of antigenic drift, and that these differences have a significant impact on the number of new infections in each flu season.
    1. Evolutionary Biology

    Molecular function limits divergent protein evolution on planetary timescales

    Mariam M Konaté et al.
    Orthologous proteins that continuously maintain the same molecular function do not usually diverge beyond a certain level of sequence and structural similarity.
    1. Developmental Biology
    2. Evolutionary Biology

    Molecular insights into the origin of the Hox-TALE patterning system

    Bruno Hudry et al.
    Interactions between Hox and TALE genes, which generate bilaterally symmetrical body plans, originated in early multicellular animals.
    1. Evolutionary Biology

    Coupling adaptive molecular evolution to phylodynamics using fitness-dependent birth-death models

    David A Rasmussen, Tanja Stadler
    A new model describes how adaptive molecular evolution shapes phylogenetic trees and can be used to estimate the fitness effects of mutations from phylogenies.
    1. Evolutionary Biology

    Convergent evolution of small molecule pheromones in Pristionchus nematodes

    Chuanfu Dong et al.
    Unexpected structural diversity of nematode small molecules, as revealed by high-resolution phylogenetic analysis, suggests recurrent biochemical innovation, a pattern that is probably typical across animals.
    1. Structural Biology and Molecular Biophysics

    Modelling dynamics in protein crystal structures by ensemble refinement

    B Tom Burnley et al.
    A combination of molecular dynamics simulations and X-ray diffraction data has been used to construct more realistic models of proteins and to provide new insights into their interactions with other proteins and biomolecules.

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