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    1. Physics of Living Systems
    2. Cell Biology

    Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation

    Robert J Huebner, Abdul Naseer Malmi-Kakkada ... John B Wallingford
    Very local molecular patterns impart precise changes in the local mechanics of individual cell-cell junctions.
    1. Neuroscience

    Corollary discharge promotes a sustained motor state in a neural circuit for navigation

    Ni Ji, Vivek Venkatachalam ... Aravinthan DT Samuel
    A primary sensory interneuron in the thermotaxis circuit of C. elegans integrates sensory input and corollary discharge to drive persistent navigational states and movement towards preferred environments.
    1. Ecology
    2. Plant Biology

    Natural genetic variation in Arabidopsis thaliana defense metabolism genes modulates field fitness

    Rachel Kerwin, Julie Feusier ... Daniel J Kliebenstein
    Environmental heterogeneity may contribute to the high levels of genetic variation in glucosinolate genes found in Arabidopsis thaliana.
    1. Cell Biology

    Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end

    Joseph M Cleary, Tae Kim ... Luke M Rice
    State-of-the-art measurements of microtubule growth combined with computational models provide new insights into the molecular mechanisms underlying microtubule elongation, including a role for GDP on the growing microtubule end.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Yeast cell responses and survival during periodic osmotic stress are controlled by glucose availability

    Fabien Duveau, Céline Cordier ... Pascal Hersen
    Microfluidic methods are used to quantitatively probe single yeast cells' response to either simultaneous or sequential stresses, revealing the dynamic interplay between two antagonistic inputs, osmotic stress and glucose starvation.
    1. Computational and Systems Biology

    Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies

    Wen Yan, Saad Ansari ... Michael Shelley
    aLENS implements new parallel methods to resolve cytoskeletal assembly dynamics with high stability, physical consistency, and scalability.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid

    Ximena Steinberg, Marina A Kasimova ... Sebastian E Brauchi
    Single-molecule measurement of conformational dynamics using a genetically encoded fluorescent probe suggests that the selectivity filter region of TRPV1 channels undergoes dynamic motion during agonist activation.
    1. Structural Biology and Molecular Biophysics

    Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations

    Tone Bengtsen, Viktor L Holm ... Kresten Lindorff-Larsen
    Molecular simulations, small-angle X-ray and neutron scattering experiments and previously measured NMR experiments were combined to study the structure and dynamics of the proteins and lipids in a nanodisc.
    1. Structural Biology and Molecular Biophysics

    Modulation of α-synuclein aggregation amid diverse environmental perturbation

    Abdul Wasim, Sneha Menon, Jagannath Mondal
    A comprehensive exploration of α-synuclein (αS) aggregation dynamics from both macroscopic and microscopic perspectives uncovers the intricate mechanisms underlying crowder and salt-induced intensification of αS self-aggregation.
    1. Ecology

    Ocean acidification increases susceptibility to sub-zero air temperatures in ecosystem engineers and limits poleward range shifts

    Jakob Thyrring, Colin D Macleod ... Christopher DG Harley
    A novel experiment shows that ocean acidification decreases freeze tolerance in blue mussels, which may limit their ability to redistribute poleward in response to climate warming.