Ni Ji, Vivek Venkatachalam ... Aravinthan DT Samuel
A primary sensory interneuron in the thermotaxis circuit of C. elegans integrates sensory input and corollary discharge to drive persistent navigational states and movement towards preferred environments.
State-of-the-art measurements of microtubule growth combined with computational models provide new insights into the molecular mechanisms underlying microtubule elongation, including a role for GDP on the growing microtubule end.
Microfluidic methods are used to quantitatively probe single yeast cells' response to either simultaneous or sequential stresses, revealing the dynamic interplay between two antagonistic inputs, osmotic stress and glucose starvation.
Ximena Steinberg, Marina A Kasimova ... Sebastian E Brauchi
Single-molecule measurement of conformational dynamics using a genetically encoded fluorescent probe suggests that the selectivity filter region of TRPV1 channels undergoes dynamic motion during agonist activation.
Tone Bengtsen, Viktor L Holm ... Kresten Lindorff-Larsen
Molecular simulations, small-angle X-ray and neutron scattering experiments and previously measured NMR experiments were combined to study the structure and dynamics of the proteins and lipids in a nanodisc.
A comprehensive exploration of α-synuclein (αS) aggregation dynamics from both macroscopic and microscopic perspectives uncovers the intricate mechanisms underlying crowder and salt-induced intensification of αS self-aggregation.
Jakob Thyrring, Colin D Macleod ... Christopher DG Harley
A novel experiment shows that ocean acidification decreases freeze tolerance in blue mussels, which may limit their ability to redistribute poleward in response to climate warming.