Molecules in the condensed phase of biological condensates convert between transiently confined states and mobile states by forming dynamic percolated networks.

Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.

The small GTPase Rho connects GPCR signaling with PKD activity at TGN membranes and consequently anterograde trafficking to focal adhesions.

Cell fates endowed by higher Bicoid concentration require input for longer duration, demonstrating a temporally non-linear morphogen-mediated pattern formation.

Network symmetry represents a new vantage point for dissecting complex information processing characteristics in multisite modification, and the breaking of symmetry can confer ordering of modification and absolute concentration robustness.

A novel 2D-to-3D human brain organoid protocol reveals the pivotal role of FGF8 signaling in driving regional patterning and cellular diversity, while also modulating genes crucial for both normal and pathological neural development.

A combination of animal models reveal how the molecular mechanisms of exosome secretion (RalA/B-dependent) are linked to their cargo content and their function in breast cancer pre-metastatic niche formation.

Biofactoid is a tool that enables researchers to capture information about molecular interactions in a form that is both human-readable and machine-computable, thereby allowing this information to be integrated into public knowledge-bases and to be widely disseminated.

Enriching the interactome with context-specific information from proteomics helps the identification of novel regulators of macrophage activation.

Selective synapse formation in a retinal motion-sensitive circuit is orchestrated by starburst amacrine cells, which use homotypic interactions to initiate formation of a dendritic scaffold that recruits projections from circuit partners.