Tuning the strength of inter- and intra-subunit hydrogen bonds can control potassium flux across biological membranes.

Inhibitory interneuron activity is dynamically modulated in new environments while individual interneurons show consistent levels of activity modulation across multiple environments, suggesting functional specialization of inhibitory subnetworks.

Cryo-EM shows that the NADase activity of SARM1 is allosterically inhibited by physiological concentrations of NAD+ that stabilizes an auto-inhibited conformation of SARM1, explaining how NAD+ depletion may inflict neurodegeneration.

Functional imaging (fMRI) across four mammalian species maps the brain areas engaging in burst-suppression activity during anesthesia, and uncovers differences between primates and rodents.

Xanthones produced by the filamentous fungus Aspergillus nidulans protect its sexual structures from predation by arthropods.

PS1 phosphorylation at Ser367 is the potential hyperactivity-driven culprit of pathogenic change in PS1 conformation in vitro and in vivo.

aIC to mPFC connections are correlative and necessary both for taste novelty behavior and learning while the reciprocal connection from mPFC to aIC is correlative and necessary for novelty behavior.

A combination of single-cell RNA sequencing of the developing septum and genetic fate mapping is used to analyze the origin of septal neurons.

The great pond snail is a multipurpose model organism and a contemporary choice for addressing a wide range of biological questions, problems and phenomena in the laboratory and the field.

FlyBrainLab is an open-source computing platform that integrates 3D exploration and visualization of diverse Drosophila connectomic/synaptomic datasets with interactive exploration of the functional logic of modeled executable brain circuits.