7,507 results found
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Genome-wide Estrogen Receptor-α activation is sustained, not cyclical

    Andrew N Holding, Amy E Cullen, Florian Markowetz
    Activation of the Estrogen Receptor by estra-2-diol results in sustained binding and the previously described cyclical response kinetics are likely an artefact of observing a highly variable process without replicates.
    1. Developmental Biology
    2. Neuroscience

    Direct glia-to-neuron transdifferentiation gives rise to a pair of male-specific neurons that ensure nimble male mating

    Laura Molina-García, Carla Lloret-Fernández ... Richard J Poole
    A novel developmental mechanism generates a previously undescribed pair of sex-specific proprioceptive neurons required for male-specific behaviour.
    1. Neuroscience

    Excitation and inhibition in anterior cingulate predict use of past experiences

    Jacqueline Scholl, Nils Kolling ... Matthew FS Rushworth
    Neurotransmitter balance in a region in frontal cortex controls how much people use information they have learnt to guide their behaviour.
    1. Epidemiology and Global Health

    A modelling approach to estimate the transmissibility of SARS-CoV-2 during periods of high, low, and zero case incidence

    Nick Golding, David J Price ... Freya M Shearer
    A new statistical model for tracking current and potential rates of disease transmission.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research

    Franziska Mohring, Melissa Natalie Hart ... Robert William Moon
    Optimised genome editing in P. knowlesi enables transgenic expression of a lead P. vivax vaccine candidate, revealing roles in host cell tropisms and providing tools for scalable vaccine efficacy testing.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The long non-coding RNA Dali is an epigenetic regulator of neural differentiation

    Vladislava Chalei, Stephen N Sansom ... Chris P Ponting
    Dali regulates transcription of the Pou3f3 locus locally and binds and regulates active promoters in trans by modulating DNA methylation status.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Investigating the trade-off between folding and function in a multidomain Y-family DNA polymerase

    Xiakun Chu, Zucai Suo, Jin Wang
    The physical interaction network encoded in the multi-domain protein native structure handles the trade-off between the fast, stable folding and the efficient, reliable function.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity

    Tamara M Sirey, Kenny Roberts ... Chris P Ponting
    Mitochondrial energy metabolism is post-transcriptionally regulated through an interplay between long and short non-coding RNAs.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A

    Friederike Roger, Cecilia Picazo ... Mikael Molin
    The major cytosolic yeast peroxiredoxin Tsa1 controls aging and H2O2-resistance by inhibiting protein kinase A through a conserved cysteine in the catalytic subunit activation loop and not by scavenging H2O2.
    1. Neuroscience

    Cerebral blood flow and cerebrovascular reactivity are preserved in a mouse model of cerebral microvascular amyloidosis

    Leon P Munting, Marc Derieppe ... Louise van der Weerd
    The causal link between capillary amyloid‑β accumulation in the brain and cerebrovascular dysfunction, previously established in the Tg‑SwDI mouse model, is to be mitigated and remains to be fully uncovered.

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