350 results found
    1. Ecology
    2. Physics of Living Systems

    Microbial consortia at steady supply

    Thibaud Taillefumier, Anna Posfai ... Ned S Wingreen
    In a consumer-resource model obeying the physical requirement of flux conservation, metabolic competition between microbes yields consortia of cell types that collectively resist invasion via optimal use of resources.
    1. Neuroscience

    Multi-scale mapping along the auditory hierarchy using high-resolution functional UltraSound in the awake ferret

    Célian Bimbard, Charlie Demene ... Yves Boubenec
    Functional UltraSound imaging allows mapping tonotopic organisation in multiple auditory subcortical and cortical brain structures with an unprecedented spatial functional resolution, while giving access to long-distance top-down connectivity pattern from frontal cortex to auditory cortex.
    1. Ecology

    Role of immigrant males and muzzle contacts in the uptake of a novel food by wild vervet monkeys

    Pooja Dongre, Gaëlle Lanté ... Erica van de Waal
    New immigrants triggered fast uptake of a novel food in groupmates, who obtained information about it through muzzle contacts, opening up new questions about the role of dispersers in information flow around a population.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pyphe, a python toolbox for assessing microbial growth and cell viability in high-throughput colony screens

    Stephan Kamrad, María Rodríguez-López ... Jürg Bähler
    An open-source python package for phenotype analyses provides a versatile, modular and user-friendly solution to determine complementary fitness-related traits from large-scale assays of microbial colonies.
    1. Stem Cells and Regenerative Medicine

    Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells

    Kevin L Lu, Jonathan O Nelson ... Yukiko M Yamashita
    rDNA copy number is shown to dynamically change during aging and through generations, and is actively maintained in male germline of Drosophila.
    1. Developmental Biology

    SlitC-PlexinA1 mediates iterative inhibition for orderly passage of spinal commissural axons through the floor plate

    Hugo Ducuing, Thibault Gardette ... Valerie Castellani
    A combination of in vivo models and imaging techniques reveals the distribution of guidance cues and their mechanisms of action during commissural axon navigation of intermediate target.
    1. Neuroscience

    Action sequence learning, habits, and automaticity in obsessive-compulsive disorder

    Paula Banca, Maria Herrojo Ruiz ... Trevor W Robbins
    Habit-based theories of obsessive-compulsive disorder are further elucidated by employing mobile phone motor sequence training, for which patients exhibited equivalent automatization, but enhanced value for the trained sequence, potentially ameliorating symptoms.
    1. Neuroscience

    Why the brown ghost chirps at night

    Livio Oboti, Federico Pedraja ... Rüdiger Krahe
    Electric signals produced by weakly electric gymnotiform fish, long seen as communication attempts, may also serve to localize conspecifics, revealing a distinct functional role.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Understanding patterns of HIV multi-drug resistance through models of temporal and spatial drug heterogeneity

    Alison F Feder, Kristin N Harper ... Pleuni S Pennings
    In triple-drug-treated HIV, partially resistant viruses can spread and resistance to specific drugs evolves in a predictable order, potentially a result of spatial or temporal heterogeneity in drug concentrations.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

    Ziva Vuckovic, Jinan Wang ... David M Thal
    Structural biology studies reveal the importance of protein dynamics on understanding molecular mechanisms underlying allosteric modulation of G protein-coupled receptors (GPCR) that offer insights into future GPCR research and drug discovery.

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