968 results found
    1. Immunology and Inflammation

    Defining murine monocyte differentiation into colonic and ileal macrophages

    Mor Gross-Vered et al.
    Detailed analysis of the sequence of monocyte differentiation into distinct gut tissue macrophages provides insights into monocyte biology and can serve as a platform for the design of cell therapies.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model

    Corbin SC Johnson et al.
    Modern human diet patterns alter primate behavior and monocyte gene expression leading to monocyte polarization–experimental evidence of the evolutionary mismatch hypothesis.
    1. Immunology and Inflammation

    Notch and TLR signaling coordinate monocyte cell fate and inflammation

    Jaba Gamrekelashvili et al.
    Notch signaling alters TLR-induced inflammation by skewing monocyte cell fate toward patrolling monocyte differentiation at the expense of macrophage cell fate.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Essential yet limited role for CCR2+ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming

    Miriam Samstein et al.
    Inflammatory monocytes carry live Mycobacteria from the lung to draining lymph nodes and acquire many characteristics of dendritic cells but fail to stimulate proliferation of CD4 T cells.
    1. Cell Biology
    2. Immunology and Inflammation

    Immune surveillance of the lung by migrating tissue monocytes

    Mathieu P Rodero et al.
    Monocytes display distinct migratory and functional activity compared to dendritic cells and alveolar macrophages in the lungs.
    1. Microbiology and Infectious Disease

    Single cell analysis reveals human cytomegalovirus drives latently infected cells towards an anergic-like monocyte state

    Miri Shnayder et al.
    Single-cell and bulk expression analyses reveal that HCMV latent infection drives cells towards a weaker immune-responsive state, which is important for its expression and reactivation.
    1. Microbiology and Infectious Disease

    Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1

    Shida Shangguan et al.
    Using single-cell CITE-seq to implicate monocytes as the cellular origin of a protective HIV vaccine gene signature.
    1. Cell Biology

    A genetic screen identifies new steps in oocyte maturation that enhance proteostasis in the immortal germ lineage

    Madhuja Samaddar et al.
    A whole-genome genetic screen links new aspects of oocyte maturation to proteostasis renewal in the immortal Caenorhabditis elegans germ-cell lineage and reveals similarities to somatic cell maintenance during aging.
    1. Immunology and Inflammation
    2. Medicine

    Expansion of CD10neg neutrophils and CD14+HLA-DRneg/low monocytes driving proinflammatory responses in patients with acute myocardial infarction

    Daniela Fraccarollo et al.
    Immature CD10neg neutrophils and CD14+HLA-DRneg/low monocytes inducing proinflammatory and adaptive immune responses emerge in patients with large acute myocardial infarction.
    1. Cell Biology
    2. Developmental Biology

    Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling

    Arul Subramanian et al.
    Perturbation of mechanical force at muscle attachments and its effects on tendon morphogenesis provides insights into the mechanisms underlying cellular responses to tensional force and resulting extracellular matrix production.

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