Stable isotope labeling reveals that NAD crosses the inner membrane of mammalian mitochondria via an unknown transporter.

An artificially evolved ribozyme can catalyse the synthesis of RNA by using trinucleotide triphosphates as building blocks.

The availability of an essential dietary micronutrient is evaluated by an intestinal signaling system that in turn regulates food-uptake and response behaviors by modulating protease expression.

Optogenetic control of Cdc42 activation during polarization of budding yeast demonstrates a cell cycle regulated switch between two distinct modes of positive feedback.

Genetic analyses reveal how CDX2 and BRAF defects seen in serrated colorectal cancer (CRCs), a poor prognosis CRC subset, cooperate in tumorigenesis in humans and in a mouse cancer model.

A comparative study of modern proteins identifies 40 fragments that may represent the observable remnants of a primordial RNA-peptide world.

Drosophila has almost all transcription factor binding specificities available to humans; and human transcription factors with divergent specificities operate in cell types that are not found in fruit flies.

Two distinct processes drive coordinated synthesis of purine and pyridine (NAD⁺) nucleotides in response to AICAR derivatives and ATP.

Direct control of ligand binding half-life with light shows that lifetime strongly affects T cell signaling.

Modelling beta-amyloid deposition in bioengineered human vessels represents a notable advance to further investigate the role of the vasculature in Alzheimer's disease.