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    1. Ecology
    2. Physics of Living Systems

    Spatial dilemmas of diffusible public goods

    Benjamin Allen, Jeff Gore, Martin A Nowak
    A simple model reveals the roles of colony geometry and diffusion rate in allowing microbes to cooperate by sharing public goods.
    1. Microbiology and Infectious Disease

    Cell cycle constraints on capsulation and bacteriophage susceptibility

    Silvia Ardissone, Coralie Fumeaux ... Patrick H Viollier
    A multi-layered and conserved cell cycle mechanism prevents capsulation, long known as a bacterial virulence determinant, in G1-phase and concurrently licenses bacteriophage-mediated genetic exchange prior to entry into S-phase.
    1. Biochemistry and Chemical Biology

    High-throughput Automated Muropeptide Analysis (HAMA) Reveals Peptidoglycan Composition of Gut Microbial Cell Walls

    Ya-Chen Hsu, Pin-Rui Su ... Cheng-Chih Hsu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology

    The ‘ForensOMICS’ approach for postmortem interval estimation from human bone by integrating metabolomics, lipidomics, and proteomics

    Andrea Bonicelli, Hayley L Mickleburgh ... Noemi Procopio
    The integration of multiple omics panels obtained from bone tissue could aid in the evaluation of the postmortem interval in forensic investigations, expanding the boundaries of forensic research.
    1. Neuroscience

    Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar

    Ana I Domingos, Aylesse Sordillo ... Jeffrey M Friedman
    Natural sugars are preferred over artificial sweeteners because of their nutritional content, which is sensed by MCH neurons in the lateral hypothalamus.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Salmonella Typhi and Salmonella Paratyphi A elaborate distinct systemic metabolite signatures during enteric fever

    Elin Näsström, Nga Tran Vu Thieu ... Henrik Antti
    Metabolite analysis of plasma from enteric fever patients define signals of organism specific host–pathogen interactions and provides opportunities for new diagnostics.
    1. Neuroscience

    Taste sensing and sugar detection mechanisms in Drosophila larval primary taste center

    G Larisa Maier, Nikita Komarov ... Simon G Sprecher
    Drosophila larvae show taste multimodality and combinatorial sensing at gustatory organ level but also systemically as they employ complementary external and internal taste in sugar detection.
    1. Cell Biology
    2. Neuroscience

    Tissue-specific O-GlcNAcylation profiling identifies substrates in translational machinery in Drosophila mushroom body contributing to olfactory learning

    Haibin Yu, Dandan Liu ... Kai Yuan
    Brain region-specific profiling of O-GlcNAcylation interactome in Drosophila mushroom body suggests that hypo-O-GlcNAcylation impacts cognitive function by regulating translational activity.
    1. Medicine

    Exploration of the metabolomic mechanisms of postmenopausal hypertension induced by low estrogen state

    Yao Li, Hui Xin ... Wei Zhang
    Low estrogen levels in postmenopausal hypertension are linked to metabolic reprogramming and aortic tissue changes, with L-alpha-aminobutyric acid emerging as a potential protective biomarker.
    1. Cell Biology
    2. Neuroscience

    Identification of a critical sulfation in chondroitin that inhibits axonal regeneration

    Craig S Pearson, Caitlin P Mencio ... Herbert M Geller
    4-sulfation at the non-reducing end of chondroitin sulfate glycosaminoglycan chains is essential for inhibition of axonal growth.