4 results found
    1. Genetics and Genomics

    Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates

    Zachary Baker, Molly Schumer ... Molly Przeworski
    PRDM9 is widely conserved across vertebrates yet has been lost numerous times, as has its role in directing meiotic recombination.
    1. Epidemiology and Global Health
    2. Medicine

    Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

    Manoj M Lalu, Katrina J Sullivan ... Lauralyn McIntyre
    A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
    1. Evolutionary Biology

    Mammalian forelimb evolution is driven by uneven proximal-to-distal morphological diversity

    Priscila S Rothier, Anne-Claire Fabre ... Anthony Herrel
    The diversification of hand bones in mammals was much more dynamic than those of the proximal and intermediate forearm, involving higher morphological diversity, stronger integration, and greater evolutionary lability at distal structures.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    In-silico analysis of myeloid cells across the animal kingdom reveals neutrophil evolution by colony-stimulating factors

    Damilola Pinheiro, Marie-Anne Mawhin ... Kevin J Woollard
    In-silico modeling of gene and protein emergence reveals how colony-stimulating factors contributed to the evolution and functional adaptions observed in mammalian neutrophils.

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