231 results found
    1. Developmental Biology

    Feedback regulation of cytoneme-mediated transport shapes a tissue-specific FGF morphogen gradient

    Lijuan Du et al.
    FGF morphogen gradient self-generates a recipient tissue-specific contour by feedback-regulating its cytoneme-mediated dispersion.
    1. Developmental Biology

    Extracellular interactions and ligand degradation shape the nodal morphogen gradient

    Yin Wang et al.
    Diffusivity, extracellular interactions of Nodal ligands with the receptors and inhibitors, and selective ligand destruction collectively shape the Nodal morphogen gradient.
    1. Developmental Biology

    Response to Nodal morphogen gradient is determined by the kinetics of target gene induction

    Julien Dubrulle et al.
    A kinetic model of morphogen interpretation is more suitable than classic threshold or ratchet models to understand how a signal gradient generates different target gene expression patterns.
    1. Physics of Living Systems

    Diffusion vs. direct transport in the precision of morphogen readout

    Sean Fancher, Andrew Mugler
    A theory predicts whether diffusion or direct transport establishes a more precise morphogen profile, and this prediction explains data from a wide variety of morphogens in two different organisms.
    1. Developmental Biology

    The Wg and Dpp morphogens regulate gene expression by modulating the frequency of transcriptional bursts

    Rachael Bakker et al.
    Experimental results in Drosophila support a model in which gene expression is fundamentally controlled by morphogens tuning the same transcription parameter for genes that are expressed in highly diverse patterns.
    1. Computational and Systems Biology
    2. Developmental Biology

    Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells

    Idse Heemskerk et al.
    Live cell imaging demonstrates that the dynamics of ligand presentation influence signaling through two closely related morphogen signaling pathways in dramatically different ways.
    1. Developmental Biology

    Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo

    Anqi Huang et al.
    Cell fates endowed by higher Bicoid concentration require input for longer duration, demonstrating a temporally non-linear morphogen-mediated pattern formation.
    1. Cell Biology
    2. Developmental Biology

    Drosophila hedgehog can act as a morphogen in the absence of regulated Ci processing

    Jamie C Little et al.
    Hedgehog acts as a morphogen by regulating proteolytic processing and activation of full-length Ci/Gli transcriptional effectors but can pattern Drosophila wing discs normally in the absence of regulated proteolytic processing.
    1. Developmental Biology
    2. Neuroscience

    BMPs direct sensory interneuron identity in the developing spinal cord using signal-specific not morphogenic activities

    Madeline G Andrews et al.
    Members of the BMP family of growth factors act as a reiterative code of distinct activities to direct the identities of different classes of sensory neurons in the spinal cord.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids

    Anna Yoney et al.
    The requirement for WNT signaling in mesendoderm differentiation is temporally separate from that of ACTIVIN signaling and acts to switch the output of ACTIVIN/SMAD2 from pluripotency maintenance to mesendoderm patterning.

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