117 results found
    1. Developmental Biology and Stem Cells

    Extracellular interactions and ligand degradation shape the nodal morphogen gradient

    Yin Wang et al.
    Diffusivity, extracellular interactions of Nodal ligands with the receptors and inhibitors, and selective ligand destruction collectively shape the Nodal morphogen gradient.
    1. Developmental Biology and Stem Cells

    Response to Nodal morphogen gradient is determined by the kinetics of target gene induction

    Julien Dubrulle et al.
    A kinetic model of morphogen interpretation is more suitable than classic threshold or ratchet models to understand how a signal gradient generates different target gene expression patterns.
    1. Developmental Biology and Stem Cells

    Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo

    Anqi Huang et al.
    Cell fates endowed by higher Bicoid concentration require input for longer duration, demonstrating a temporally non-linear morphogen-mediated pattern formation.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    BMPs direct sensory interneuron identity in the developing spinal cord using signal-specific not morphogenic activities

    Madeline G Andrews et al.
    Members of the BMP family of growth factors act as a reiterative code of distinct activities to direct the identities of different classes of sensory neurons in the spinal cord.
    1. Developmental Biology and Stem Cells
    2. Genes and Chromosomes

    Concentration dependent chromatin states induced by the bicoid morphogen gradient

    Colleen E Hannon et al.
    Interplay between protein concentration, DNA binding and remodeling of the chromatin landscape in early embryogenesis determines how a single transcription factor can specify multiple distinct gene expression states.
    1. Developmental Biology and Stem Cells

    Cytoneme-mediated cell-cell contacts for Hedgehog reception

    Laura González-Méndez et al.
    Direct interaction between Hedgehog-sending and Hedgehog-receiving cytonemes is a fundamental mechanism for morphogen transfer and gradient establishment.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Pentagone internalises glypicans to fine-tune multiple signalling pathways

    Mark Norman et al.
    Glypican proteins, required for morphogen signalling in Drosophila wing development, are endocytosed and degraded by the feedback regulator Pentagone.
    1. Developmental Biology and Stem Cells

    Jak-Stat pathway induces Drosophila follicle elongation by a gradient of apical contractility

    Hervé Alégot et al.
    A morphogen gradient can trigger tissue elongation via a control of apical cell pulsing and without a planar cell polarity requirement.
    1. Developmental Biology and Stem Cells

    Bone morphogenic protein signalling suppresses differentiation of pluripotent cells by maintaining expression of E-Cadherin

    Mattias Malaguti et al.
    The differentiation decisions made by pluripotent cells depend on their exposure to appropriate extrinsic signals and also on morphogenetic events that control receptivity to those differentiation cues.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action

    Pablo Sanchez Bosch et al.
    Striped expression of Dpp in Drosophila wing precursors leads to graded signalling activity that positions wing veins and, in parallel, promotes growth in a gradient-independent manner by supplying signalling activity above a threshold.

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