Genetic, biochemistry and modeling approaches reveal elements of a Turing-type reaction-diffusion system to control pattern formation in differentiating cyanobacterial filaments.
Analysis of axial polarity distributions shows that Wnt5a regulates collective cell migration in vivo by stabilizing vinculin at adherens junctions and fine-tuning mechanocoupling between neighbouring cells.
In the Arabidopsis epidermis, the internal mechanical stress of a cell competes with the external stress to control microtubule behavior, providing a framework to understand the mechanical feedbacks that underlie plant morphogenesis.
Computational approach quantifies the abundance of phenazine-antibiotic producing and biodegrading bacteria in diverse soil and plant-associated habitats.
Endothelial YAP/TAZ shape the developing vasculature by orchestrating mechanical inputs with BMP signalling to promote junctional VE-Cadherin turnover and cellular rearrangements.
Maternal positional information in the fly embryo can be read rapidly in spite of the gene-expression bottleneck and general examples of regulatory architectures that combine speed and accuracy are provided.
Propagation, speed and shapes of genetic waves of expression during development can be modeled by a simple interplay between two transcriptional modules (dynamic/static), which explains robustness and precision of patterning.
A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.
