Browse the search results

Page 2 of 23
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Progenitors oppositely polarize WNT activators and inhibitors to orchestrate tissue development

    Irina Matos et al.
    Progenitors establish a single-cell length WNT morphogen gradient to transmit signals directionally and differentially to neighbors.
    1. Cell Biology
    2. Developmental Biology

    Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing

    Sabine Schürmann et al.
    Proteolysis of lipidated N-terminal peptides that tether Hedgehog morphogens to the surface of source cells is absolutely required for their coupled release and bioactivation in vivo in Drosophila melanogaster.
    1. Developmental Biology

    Cytoneme-mediated cell-cell contacts for Hedgehog reception

    Laura González-Méndez et al.
    Direct interaction between Hedgehog-sending and Hedgehog-receiving cytonemes is a fundamental mechanism for morphogen transfer and gradient establishment.
    1. Cell Biology
    2. Developmental Biology

    Pentagone internalises glypicans to fine-tune multiple signalling pathways

    Mark Norman et al.
    Glypican proteins, required for morphogen signalling in Drosophila wing development, are endocytosed and degraded by the feedback regulator Pentagone.
    1. Developmental Biology

    Jak-Stat pathway induces Drosophila follicle elongation by a gradient of apical contractility

    Hervé Alégot et al.
    A morphogen gradient can trigger tissue elongation via a control of apical cell pulsing and without a planar cell polarity requirement.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids

    Anna Yoney et al.
    The requirement for WNT signaling in mesendoderm differentiation is temporally separate from that of ACTIVIN signaling and acts to switch the output of ACTIVIN/SMAD2 from pluripotency maintenance to mesendoderm patterning.
    1. Stem Cells and Regenerative Medicine

    Bone morphogenic protein signalling suppresses differentiation of pluripotent cells by maintaining expression of E-Cadherin

    Mattias Malaguti et al.
    The differentiation decisions made by pluripotent cells depend on their exposure to appropriate extrinsic signals and also on morphogenetic events that control receptivity to those differentiation cues.
    1. Cell Biology
    2. Developmental Biology

    Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action

    Pablo Sanchez Bosch et al.
    Striped expression of Dpp in Drosophila wing precursors leads to graded signalling activity that positions wing veins and, in parallel, promotes growth in a gradient-independent manner by supplying signalling activity above a threshold.
    1. Developmental Biology

    Release and spread of Wingless is required to pattern the proximo-distal axis of Drosophila renal tubules

    Robin Beaven, Barry Denholm
    In contrast to growing evidence that juxtracrine signalling accounts for Wnt/Wingless patterning function, Wingless behaves as a released signal in Drosophila renal tubule development, being secreted from the midgut to spread and pattern the proximal tubule.
    1. Cell Biology
    2. Developmental Biology

    Cleavage activates Dispatched for Sonic Hedgehog ligand release

    Daniel P Stewart et al.
    Dispatched cleavage, mediated by Furin, regulates Dispatched membrane trafficking and release of Sonic Hedgehog ligand.