High-resolution live imaging analysis shows a constriction mechanism that drives zebrafish optic cup morphogenesis and highlights the role of the extracellular matrix in transmitting tensions beyond the cellular level.
A novel ALS-associated variant in UBQLN4 impairs proteasome function and beta-catenin degradation to drive aberrant axon morphogenesis in motor neurons.
Analysis of a double mutant in the Hippo pathway transcription factors Yap1 and Wwtr1 reveals novel roles for these factors in posterior body formation and epidermal morphogenesis in the vertebrate embryo.
A precise sequence of left-right asymmetries, combined with mechanical constraints, is sufficient to drive the looped morphogenesis of the embryonic heart tube, with potential impact for congenital heart defects.
Analysing developing mouse kidneys demonstrates nephron formation does not significantly impact branching morphogenesis of the ureteric bud, suggesting this process is distinct from branching in organs like the mammary gland.
Mechanical instabilities are shown to underlie the development of bacterial biofilm morphology, suggesting an ancient origin for mechano-morphogenesis, which is known to drive developmental processes in tissues in higher organisms.
The unfolded protein response regulates neuronal dendrite morphogenesis by controlling the folding of a transmembrane leucine-rich repeat (LRR) protein.
Autonomous patterns of cell contraction in the context of localized apical extracellular matrix constraints specify tissue stresses that reshape the wing epithelium.
MorphoGraphX summarizes full 3D datasets as curved surface images (2.5D), enabling the efficient quantification of growth and gene expression data from large time-lapse volumetric datasets.
