Voice your concerns about research culture and research communication: Have your say in our 7th annual survey.
1,509 results found
    1. Computational and Systems Biology

    Systematic morphological profiling of human gene and allele function via Cell Painting

    Mohammad Hossein Rohban et al.
    Gene function can be revealed based on characteristic phenotypes using a Cell Painting microscopy assay.
    1. Genetics and Genomics

    Genetic profiling of protein burden and nuclear export overload

    Reiko Kintaka et al.
    A comprehensive analysis of yeast mutants has provided clues to understanding the physiological conditions caused by protein overexpression.
    1. Neuroscience

    A family of photoswitchable NMDA receptors

    Shai Berlin et al.
    Molecular engineering can generate light-sensitive NMDA receptors with specific subunit combinations.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes

    Timothy J de Wet et al.
    A high-throughput functional genomics approach combining inducible CRISPR-interference and quantitative imaging yields an atlas of 'phenoprints' to guide gene function assignments, identify metabolic pathway-specific morphotypes, and inform antibiotic mechanism-of-action studies.
    1. Genetics and Genomics
    2. Neuroscience

    Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons

    Kenichi Ishii et al.
    Sex-specific characteristics of the fruit fly courtship behavior are not specified by a single binary switch, but as a combination of traits that are modularly specified by separable genetic switches.
    1. Developmental Biology
    2. Neuroscience

    Enteric glia as a source of neural progenitors in adult zebrafish

    Sarah McCallum et al.
    Characterization of a novel population of enteric nervous system glial cells in zebrafish reveals their proliferative and neurogenic properties under homeostatic conditions in adults, properties difficult to model in mammals.
    1. Cell Biology
    2. Developmental Biology

    Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy

    Claudia Prahst et al.
    Improved 3D and 4D imaging of neurovascular processes across scales reveals new insights into eye disease mouse models and shows retinal vessels are significantly distorted using standard flat-mount confocal imaging.
    1. Developmental Biology
    2. Genetics and Genomics

    celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish

    Chunmei Li et al.
    The use of forward genetic screens in zebrafish identifies a new model of vertebrate aging, defining the regulating of the onset of aging phenotypes through maintenance of progenitor cell populations.
    1. Neuroscience

    An insect-like mushroom body in a crustacean brain

    Gabriella Hannah Wolff et al.
    An insect-like mushroom body in one group of crustaceans, the mantis shrimps (Stomatopoda), suggests either an ancient origin of this center and its reduction and loss in other crustaceans, or an extraordinary example of convergent evolution with the insect mushroom body.
    1. Developmental Biology

    Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification

    Rodrigo M Young et al.
    Disruptions to eye field size have little impact on final eye size due to tissue compensatory mechanisms.

Refine your results by:

Type
Research categories