237 results found
    1. Developmental Biology

    Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells

    Jonghyeob Lee et al.
    Cells from the human pancreatic duct can be grown in culture and triggered to become insulin-producing cells, which could potentially be transplanted into patients with diabetes.
    1. Developmental Biology
    2. Neuroscience

    Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons

    Thomas M Coate et al.
    The development of the mammalian cochlea undergoes a period of embryonic refinement in which the outer hair cell region repels incoming type I spiral ganglion neurons, thus ensuring these neurons instead form connections with inner hair cells.
    1. Cell Biology

    SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

    Ashutosh Kumar et al.
    LRRC8A is an essential component of a mechanoresponsive ion channel signaling complex that tunes skeletal muscle differentiation, muscle cell size, function and metabolic pathways to regulate adiposity and systemic glycemia.
    1. Plant Biology

    Temperature-dependent fasciation mutants provide a link between mitochondrial RNA processing and lateral root morphogenesis

    Kurataka Otsuka et al.
    Temperature-dependent fasciation mutants of Arabidopsis unexpectedly connect mitochondrial RNA processing to the control of cell proliferation during lateral root morphogenesis via electron transport chain activity and reactive oxygen species production.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    EphA7 promotes myogenic differentiation via cell-cell contact

    Laura L Arnold et al.
    The juxtacrine signaling molecule EphA7, when expressed on terminally-differentiated myocytes, non-cell-autonomously induces adjacent myoblasts to also commit to terminal differentiation leading to rapid coordinated differentiation across the entire population.
    1. Neuroscience

    Dreaming with hippocampal damage

    Goffredina Spanò et al.
    A provoked awakening protocol during sleep reveals that selective bilateral hippocampal damage in humans is associated with reduced frequency, quality, and content of dreaming.
    1. Genetics and Genomics
    2. Neuroscience

    Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons

    Kenichi Ishii et al.
    Sex-specific characteristics of the fruit fly courtship behavior are not specified by a single binary switch, but as a combination of traits that are modularly specified by separable genetic switches.
    1. Computational and Systems Biology
    2. Neuroscience

    The natverse, a versatile toolbox for combining and analysing neuroanatomical data

    Alexander Shakeel Bates et al.
    Open source software enables neuroscientists to integrate single neuron or synaptic-resolution datasets from different imaging modalities to analyse morphology and connectivity at the scale of whole brains and connectomes.
    1. Genetics and Genomics
    2. Neuroscience

    Layered roles of fruitless isoforms in specification and function of male aggression-promoting neurons in Drosophila

    Margot Wohl et al.
    Male-type aggressive and courtship behaviors of the fruit flies are differentially specified by two sex-determining genes, providing a substrate for the evolution to sculpt these two behaviors independently.
    1. Neuroscience

    Evolution of neuronal anatomy and circuitry in two highly divergent nematode species

    Ray L Hong et al.
    The substrate for evolutionary divergence does not lie in changes in neuronal cell number or targeting, but rather in sensory perception and synaptic partner choice within invariant, prepatterned neuronal processes.

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