176 results found
    1. Neuroscience

    Selective targeting of unipolar brush cell subtypes by cerebellar mossy fibers

    Timothy S Balmer, Laurence O Trussell
    Distinct inputs to the cerebellum make contact on specific subtypes of target neurons.
    1. Neuroscience

    The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus

    E Anne Martin et al.
    Loss of Kirrel3 selectively reduces DG-GABA mossy fiber filopodia and causes CA3 neuron hyper-activity during brain development.
    1. Neuroscience

    Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses

    Nicholas P Vyleta et al.
    Activity-dependent enhancement of transmitter release makes the hippocampal mossy fiber synapse a full detonator in rats.
    1. Neuroscience

    Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses

    Pablo J Lituma et al.
    By facilitating glutamate and BDNF release, presynaptic NMDA receptors may control information transfer from the dentate gyrus to the CA3 area of the hippocampus.
    1. Neuroscience

    RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses

    Marisa M Brockmann et al.
    The active zone scaffold protein RIM-BP2 performs distinct functions in vesicle release at two hippocampal synapses, providing insights on how synapses express diversity in release properties.
    1. Neuroscience

    Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination

    Brian W Jones et al.
    The PKA anchoring protein, AKAP7, localizes PKA in dentate granule mossy fibers and this localization plays an important role in contextual discrimination and cAMP-induced synaptic plasticity.
    1. Neuroscience

    Multimodal sensory integration in single cerebellar granule cells in vivo

    Taro Ishikawa et al.
    Building on previous work (Huang et al., 2013), it is shown that single granule cells receive excitatory synaptic input driven by up to three separate sensory modalities in vivo, which demonstrate that individual neurons can contribute to multisensory integration at the input layer of the cerebellar cortex.
    1. Neuroscience

    Synaptic representation of locomotion in single cerebellar granule cells

    Kate Powell et al.
    The first patch-clamp recordings from single cerebellar granule cells during locomotion reveal that the entire step sequence can be predicted from both excitatory synaptic input and output spikes from a single neuron.
    1. Neuroscience

    GluA4 facilitates cerebellar expansion coding and enables associative memory formation

    Katarzyna Kita et al.
    GluA4-containing AMPA receptors are required for effective excitation of cerebellar granule cells and enable expansion coding and associative learning.
    1. Neuroscience

    Quantitative properties of a feedback circuit predict frequency-dependent pattern separation

    Oliver Braganza et al.
    The feedback inhibitory microcircuit of the dentate gyrus likely boosts pattern separation during gamma oscillations.

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