566 results found
    1. Evolutionary Biology

    Whole genome phylogenies reflect the distributions of recombination rates for many bacterial species

    Thomas Sakoparnig, Chris Field, Erik van Nimwegen
    For many bacterial species, recombination dominates genome evolution and phylogenetic patterns that have so far been assumed to reflect clonal relationships, in fact reflect variation in recombination rates across lineages.
    1. Cell Biology
    2. Developmental Biology

    Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human

    Simon Schneider, Andjela Kovacevic ... Hubert Schorle
    Cylicin 1 and Cylicin 2 are essential components of the sperm perinuclear theca and their loss results in impaired spermiogenesis and thus in infertility in mice and men.
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon, Sarah E Lower ... Jing-Ke Weng
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Evolutionary Biology

    Resurrection of a global, metagenomically defined gokushovirus

    Paul C Kirchberger, Howard Ochman
    Isolation of a gokushovirus capable of lysogenizing enterobacteria challenges previous notions about the biology of the most prolific phages within the Microviridae and facilitates experimental study in a model organism.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pathway dynamics can delineate the sources of transcriptional noise in gene expression

    Lucy Ham, Marcel Jackson, Michael PH Stumpf
    There are fundamental limits to what can be learned about the origins of transcriptional noise from gene expression data alone, which can be overcome by simultaneously quantifying the abundances of linked molecular species.
    1. Neuroscience

    A transient postnatal quiescent period precedes emergence of mature cortical dynamics

    Soledad Domínguez, Liang Ma ... Jennifer N Gelinas
    Maturation of cortical network dynamics is characterized by a nadir that signals the shift from local, loosely correlated, prominently sensory-driven patterns to internally organized, spatially distributed, and temporally precise activity.
    1. Developmental Biology
    2. Genetics and Genomics

    The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion

    Damian Kao, Alvina G Lai ... Aziz Aboobaker
    The first malacostracan genome sequence will establish the genetically tractable Parhyale hawaiensis as a model organism in this key animal group.
    1. Developmental Biology

    A MSTNDel73C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

    Ming-Ming Chen, Yue Zhao ... Zheng-Xing Lian
    Newly prepared double gene-edited sheep provide excellent models for skeletal muscle growth and development, and muscle diseases such as muscle atrophy and sarcopenia.
    1. Physics of Living Systems

    Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock

    Paul Gerald Layague Sanchez, Victoria Mochulska ... Alexander Aulehla
    A microfluidic experimental approach combined with dynamical systems theory reveals how to entrain an embryonic oscillator, the segmentation clock, and allows for the quantification of its entrainment properties.
    1. Cell Biology
    2. Plant Biology

    Members of the ELMOD protein family specify formation of distinct aperture domains on the Arabidopsis pollen surface

    Yuan Zhou, Prativa Amom ... Anna A Dobritsa
    Pollen aperture patterning in Arabidopsis is controlled by members of the ELMOD protein family, whose expression levels in developing pollen lineage are tightly regulated.

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