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    1. Cell Biology
    2. Computational and Systems Biology

    Determining growth rates from bright-field images of budding cells through identifying overlaps

    Julian MJ Pietsch, Alán F Muñoz ... Peter S Swain
    The BABY algorithm by estimating growth rates of individual cells from time-lapse microscopy images will help characterise the diversity in populations of budding cells, particularly differences in fitness.
    1. Epidemiology and Global Health

    Asymptomatic Bordetella pertussis infections in a longitudinal cohort of young African infants and their mothers

    Christopher J Gill, Christian E Gunning ... Pejman Rohani
    Longitudinal qPCR-based pertussis surveillance of a low-resource African cohort reveals frequent asymptomatic pertussis infections in both young infants and mothers and suggests possible early warning signals for epidemic outbreaks.
    1. Genetics and Genomics
    2. Plant Biology

    Genetic basis of sRNA quantitative variation analyzed using an experimental population derived from an elite rice hybrid

    Jia Wang, Wen Yao ... Qifa Zhang
    The expression of small RNAs (or sRNAs) is regulated not only by mRNA expression, but also by their own regulatory elements and by sRNA biogenesis genes.
    1. Ecology
    2. Microbiology and Infectious Disease

    Immune-mediated hookworm clearance and survival of a marine mammal decrease with warmer ocean temperatures

    Mauricio Seguel, Felipe Montalva ... Nicole Gottdenker
    In years with colder ocean temperatures, fur seal pups receive more maternal care and have a better energy balance, clearing hookworm infection earlier, which increases their chances of survival.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Light-driven synchronization of optogenetic clocks

    Maria Cristina Cannarsa, Filippo Liguori ... Roberto Di Leonardo
    Introducing the optorepressilator, a synthetic genetic oscillator that can be synchronized, entrained, and detuned by green light to precisely control periodic gene expression in single cells or entire bacterial populations.
    1. Medicine
    2. Epidemiology and Global Health

    Reducing respiratory syncytial virus (RSV) hospitalization in a lower-income country by vaccinating mothers-to-be and their households

    Samuel PC Brand, Patrick Munywoki ... David James Nokes
    Targeting the mothers, and other household members, of newborns with a mixture of respiratory syncytial virus (RSV) vaccines is both efficient and effective at reducing RSV hospitalizations.
    1. Cell Biology
    2. Developmental Biology

    Protein aggregates are associated with replicative aging without compromising protein quality control

    Juha Saarikangas, Yves Barral
    The aging lineage of budding yeast is differentiated by an early-appearing protein deposit that promotes protein quality control.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pneumococcal genetic variability in age-dependent bacterial carriage

    Philip HC Kremer, Bart Ferwerda ... John A Lees
    Future vaccination strategies in pneumococcal disease should target specific bacterial serotypes for different host age groups.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Visualizing the functional architecture of the endocytic machinery

    Andrea Picco, Markus Mund ... Marko Kaksonen
    A combination of light and electron microscopy data provide new insights into the dynamic architecture and the function of the endocytic protein machinery in relation to membrane shape changes in vivo.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Cell-wall remodeling drives engulfment during Bacillus subtilis sporulation

    Nikola Ojkic, Javier López-Garrido ... Robert G Endres
    Imaging experiments and simulations reveal that the biophysical mechanism for force generation needed to engulf a forespore is based on coordinated cell wall synthesis and degradation.