During neurotransmitter release, calcium-induced membrane insertion of the C2B domain of Synaptotagmin re-orients the bound SNARE complex which dilates the fusion pore in a mechanical lever action.

A university genomics class provides detailed examples of how to design and execute Oxford Nanopore MinION hackathons as part of an academic curriculum.

Uniting two principles that have been thought of being mutually exclusive in the past can explain how neurons become sensitive to the direction of motion.

Connectomic analysis identifies the complex circuits of a visual motion-sensing neuron that qualify them to generate direction-selective motion sensing signals using both Hassenstein-Reichardt and Barlow-Levick models.

The linguistic characteristics of peer review reports are not influenced by research area, type of review or reviewer gender, which is evidence for the robustness of peer review.

The cortical grasping circuit separates but shares visual and motor processes to transform object attributes into appropriate hand movements.

IQ domain phosphorylation regulates calmodulin binding and myosin-1 function.

DNA fingerprinting by portable nanopore sequencing is a novel re-identification method with applications in (clinical) laboratories and biobanks.

Animal-to-animal variability in neural circuit elements is often hidden under normal conditions, but becomes functionally relevant when the system is challenged by injury.

Spontaneous fusion of vesicles at synapses is regulated independently of fusion triggered by action potentials, adding to evidence that the two types of fusion have distinct functions.