9,081 results found
    1. Neuroscience
    2. Physics of Living Systems

    The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores

    Zhenyong Wu et al.
    During neurotransmitter release, calcium-induced membrane insertion of the C2B domain of Synaptotagmin re-orients the bound SNARE complex which dilates the fusion pore in a mechanical lever action.
  1. Cutting Edge: Using mobile sequencers in an academic classroom

    Sophie Zaaijer et al.
    A university genomics class provides detailed examples of how to design and execute Oxford Nanopore MinION hackathons as part of an academic curriculum.
    1. Neuroscience

    Complementary mechanisms create direction selectivity in the fly

    Juergen Haag et al.
    Uniting two principles that have been thought of being mutually exclusive in the past can explain how neurons become sensitive to the direction of motion.
    1. Neuroscience

    The comprehensive connectome of a neural substrate for ‘ON’ motion detection in Drosophila

    Shin-ya Takemura et al.
    Connectomic analysis identifies the complex circuits of a visual motion-sensing neuron that qualify them to generate direction-selective motion sensing signals using both Hassenstein-Reichardt and Barlow-Levick models.
  2. Meta-Research: Large-scale language analysis of peer review reports

    Ivan Buljan et al.
    The linguistic characteristics of peer review reports are not influenced by research area, type of review or reviewer gender, which is evidence for the robustness of peer review.
    1. Neuroscience

    Object vision to hand action in macaque parietal, premotor, and motor cortices

    Stefan Schaffelhofer, Hansjörg Scherberger
    The cortical grasping circuit separates but shares visual and motor processes to transform object attributes into appropriate hand movements.
    1. Cell Biology

    TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium

    Karen Baker et al.
    IQ domain phosphorylation regulates calmodulin binding and myosin-1 function.
    1. Cell Biology
    2. Genetics and Genomics

    Rapid re-identification of human samples using portable DNA sequencing

    Sophie Zaaijer et al.
    DNA fingerprinting by portable nanopore sequencing is a novel re-identification method with applications in (clinical) laboratories and biobanks.
    1. Neuroscience

    Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury

    Akira Sakurai et al.
    Animal-to-animal variability in neural circuit elements is often hidden under normal conditions, but becomes functionally relevant when the system is challenged by injury.
    1. Cell Biology
    2. Neuroscience

    Fast retrieval and autonomous regulation of single spontaneously recycling synaptic vesicles

    Jeremy Leitz, Ege T Kavalali
    Spontaneous fusion of vesicles at synapses is regulated independently of fusion triggered by action potentials, adding to evidence that the two types of fusion have distinct functions.

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